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Vol. 13, No. 1, 2006
Issue release date: August 2006
Section title: Original Paper
Neuroimmunomodulation 2006;13:28–35
(DOI:10.1159/000093271)

Estradiol, but Not Dehydroepiandrosterone, Decreases Parasitemia and Increases the Incidence of Cerebral Malaria and the Mortality in Plasmodium berghei ANKA-Infected CBA Mice

Libonati R.M.F.a · Cunha M.G.b · Souza J.M.d · Santos M.V.N.c · Oliveira S.G.d · Daniel-Ribeiro C.T.d · Carvalho L.J.M.e · do Nascimento J.L.M.c
aNúcleo de Medicina Tropical, bDepartamento de Patologia e cDepartamento de Fisiologia, Universidade Federal do Pará, dInstituto Evandro Chagas, Secretaria de Vigilância Sanitária, Belém, e eDepartamento de Imunologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brasil

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/17/2005
Accepted: 12/31/2005
Published online: 8/8/2006
Issue release date: August 2006

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM

Abstract

Objective: The effect of castration and subsequent replacement of dehydroepiandrosterone (DHEA) or estradiol on parasitemia, mortality and incidence of cerebral malaria (CM) was evaluated in CBA mice infected with Plasmodium berghei ANKA. Methods: Female mice were castrated, and groups of 12–15 animals received daily injections of DHEA, estradiol or saline. Four days after the start of treatment, mice were inoculated with 1 × 106P. berghei ANKA-parasitized erythrocytes. DHEA treatment was continued during the 5 days after infection, and estradiol was administered during the follow-up. Parasitemia was evaluated daily in Giemsa-stained blood smears. Signs of CM were determined by the manifestation of coma, limb paralysis and/or convulsions. Plasma TNF-α levels were evaluated by sandwich ELISA. Nitric oxide synthase (NOS) activity in the brain of moribund mice was measured by the method of Bredt and Snyder. Results: In non-castrated infected mice, the incidence of CM was 50%, and plasma TNF-α increased and brain NOS activity decreased compared to non-infected controls. Castration had no major effect on the parameters analyzed (parasitemia, mortality, CM incidence, TNF-α levels or NOS activity). Estradiol replacement caused a decrease in parasitemia but resulted in higher CM incidence and faster mortality, with an increase in NOS activity. Conclusions: Estradiol modulated the immune response of P. berghei ANKA-infected CBA mice, decreasing parasitemia and increasing NOS activity, and impacted negatively on survival and CM incidence, showing that neuroimmunoendocrine interactions are important in the physiopathogenesis of malaria infections.

© 2006 S. Karger AG, Basel


  

Author Contacts

José Luís Martins do Nascimento
Departamento de Fisiologia, Centro de Ciencias Biologicas
Universidade Federal do Pará
Rua Augusto Correa No. 1, Campus do Guamá, 66075-110 Belém, PA (Brazil)
Tel. +55 91 3183 1202, E-Mail jlmn@ufpa.br

  

Article Information

Received: October 17, 2005
Accepted: December 31, 2005
Published online: May 12, 2006
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 0, Number of References : 52

  

Publication Details

Neuroimmunomodulation

Vol. 13, No. 1, Year 2006 (Cover Date: August 2006)

Journal Editor: Chrousos, G.P. (Bethesda, Md.)
ISSN: 1021–7401 (print), 1423–0216 (Online)

For additional information: http://www.karger.com/NIM


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/17/2005
Accepted: 12/31/2005
Published online: 8/8/2006
Issue release date: August 2006

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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