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Original Research

Non-Invasive Resting Magnetocardiographic Imaging for the Rapid Detection of Ischemia in Subjects Presenting with Chest Pain

Tolstrup K.a · Madsen B.E.b · Ruiz J.A.a · Greenwood S.D.a · Camacho J.a · Siegel R.J.a · Gertzen H.C.b · Park J.-W.c · Smars P.A.b

Author affiliations

aCedars-Sinai Medical Center, Division of Cardiology, Los Angeles, Calif., and bMayo Clinic College of Medicine, Department of Emergency Medicine, Rochester, Minn., USA; cKlinikum Hoyerswerda, Division of Cardiology, Hoyerswerda, Germany

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Cardiology 2006;106:270–276

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: August 11, 2005
Accepted: February 28, 2006
Published online: November 15, 2006
Issue release date: November 2006

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Background: Early diagnosis of ischemia is complicated by the poor sensitivity of standard tests and contraindication for stress testing in unstable angina patients. Magnetocardiography (MCG) imaging can be used for the rapid, non-invasive detection of ischemia at rest. Methods: We studied 125 patients with presumed ischemic chest pain. All were chest pain free at the time of scanning. A 6-minute resting MCG scan (CardioMag Imaging, Inc., New York, 9-channel system) was performed. Following the MCG scan, automated software data analysis was performed, and quantitative scores were automatically calculated for each subject. The presence of ischemia was determined after testing with serial troponins, stress testing, and/or coronary angiography. Results: The mean age was 59.4 ± 13.6 years. Most patients (86.4%) had non-ischemic 12-lead ECG and normal troponin (86.2%). Fifty-five patients (44.0%) were determined to be ischemic. The MCG sensitivity, specificity, positive and negative predictive value was 76.4, 74.3, 70.0 and 80.0%, respectively, for the detection of ischemia (p < 0.0001). Conclusions: MCG is a new rapid, non-invasive imaging tool able to detect repolarization abnormalities at rest consistent with ischemia in patients presenting with chest pain syndrome and normal or non-specific 12-lead ECG and normal troponin.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: August 11, 2005
Accepted: February 28, 2006
Published online: November 15, 2006
Issue release date: November 2006

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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