PSORS2 Markers Are Not Associated with Psoriatic Arthritis in the Italian PopulationGiardina E. · Predazzi I. · Sinibaldi C. · Peconi C. · Amerio P. · Costanzo A. · Paradisi A. · Capizzi R. · Paradisi M. · Chimenti S. · Taccari E. · Novelli G.
aCentre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, Tor Vergata University of Rome, Rome, bDermatological Unit, University of Chieti, Chieti, cDepartment of Dermatology, University of Rome, ‘Tor Vergata’, dDepartment of Dermatology, Catholic University of Sacred Heart, eVII Division, Pediatric Dermatology, Istituto Dermopatico Dell’Immacolata IRCCS, fDepartment of Applied Medical and Clinical Therapy, Division of Rheumatology, University ‘La Sapienza’, and gOspedale S. Pietro Fatebenefratelli, Roma, Italy; hDivision of Cardiovascular Medicine, Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, Ark., USA
Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy characterized by the association of arthritis and psoriasis (Ps). The precise etiology of PsA is unknown, but epidemiological studies supported the existence of a genetic component for the disease. Here we report an association study on a large PsA Italian cohort for DNA variants recently reported as associated alleles at PSORS2 (17q25) in Ps cohorts from the US. We focused on discovering a possible involvement of PSORS2 associated SNPs in pathogenesis of PsA. We selected two SNPs (rs7420, rs734232) within the proximal peak and two SNPs (rs869190 and rs1561946) within distal peak of PSORS2. Our results ruled out PSORS2 alleles as susceptibility factors in arthritis psoriatic patients of Italian origin and suggested that previous linkage signal reported for chromosome 17q25 should be independent on the presence of PsA.
Via Montpellier, 1
IT–00133 Roma (Italy)
Tel. +39 06 7259 6072, +39 06 2090 0665, Fax +39 06 2090 0669
Received: January 20, 2006
Accepted after revision: March 28, 2006
Published online: May 30, 2006
Number of Print Pages : 3
Number of Figures : 0, Number of Tables : 1, Number of References : 10
Human Heredity (International Journal of Human and Medical Genetics)
Vol. 61, No. 2, Year 2006 (Cover Date: June 2006)
Journal Editor: Devoto, M. (Philadelphia, Pa.)
ISSN: 0001–5652 (print), 1423–0062 (Online)
For additional information: http://www.karger.com/HHE