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Vol. 66, No. 2, 2006
Issue release date: July 2006
Section title: Novel Insights from Clinical Practice
Horm Res 2006;66:89–93
(DOI:10.1159/000093693)

Portal Vein Thrombosis and High Factor VIII in Turner Syndrome

Kopacek Zilz C.a · Keller Brenner J.b · Elnecave R.H.a
aServiço de Endocrinologia, Hospital de Clínicas de Porto Alegre, and bUniversidade Federal do Rio Grande do Sul, Faculdade de Medicina, Porto Alegre, Brazil

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Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 10/19/2005
Accepted: 2/22/2006
Published online: 7/26/2006
Issue release date: July 2006

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Backgrounds/Aims: Turner syndrome is not usually associated with thrombotic events. The aim of this study is to report 3 Turner syndrome patients with portal vein thrombosis and, in 2 of them, high factor VIII. These findings are compared to values in Turner syndrome patients without thrombosis and controls. Methods: In different years, 3 patients with Turner syndrome were initially seen at the Gastroenterology Clinic of Hospital de Clínicas de Porto Alegre, Brazil, for portal vein thrombosis. After the most common causes of portal vein thrombosis and thrombophilias had been excluded, the 2 surviving patients were studied for clotting factors VIII, IX and von Willebrand factor. The same factors were also assessed in 25 Turner syndrome patients without thrombosis and 25 normal girls. Results: One of the patients with portal vein thrombosis died before the study. In the 2 surviving patients, factors VIII and von Willebrand levels were >150 IU/dl, which is considered to be high. In Turner syndrome patients without thrombosis, the mean factor VIII level was 127.2 ± 41.1 IU/dl and for von Willebrand factor 101.2 ± 26.9 IU/dl, while in control girls these were 116.0 ± 27.6 and 94.28 ± 27.5 IU/dl, respectively. Factor VIII and von Willebrand factor were not different between these 2 groups. When non-O blood group Turner syndrome patients and normal girls were compared, the former had significantly higher levels of factor VIII. Conclusions: This is the first report on the unusual finding of portal thrombosis in patients with Turner syndrome in whom high levels of factor VIII and von Willebrand factor were found. Factor VIII is higher in the non-O blood group Turner syndrome patients without thrombosis when compared to normal girls.

© 2006 S. Karger AG, Basel


  

Article Information

Received: October 19, 2005
Accepted: April 19, 2006
Published online: May 31, 2006
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 2, Number of References : 36

  

Publication Details

Hormone Research (From Developmental Endocrinology to Clinical Research)

Vol. 66, No. 2, Year 2006 (Cover Date: July 2006)

Journal Editor: Czernichow, P. (Paris)
ISSN: 0301–0163 (print), 1423–0046 (Online)

For additional information: http://www.karger.com/HRE


Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 10/19/2005
Accepted: 2/22/2006
Published online: 7/26/2006
Issue release date: July 2006

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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