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Vol. 61, No. 3, 2006
Issue release date: August 2006
Section title: Original Paper
Hum Hered 2006;61:132–143
(DOI:10.1159/000093774)

Iran: Tricontinental Nexus for Y-Chromosome Driven Migration

Regueiro M. · Cadenas A.M. · Gayden T. · Underhill P.A. · Herrera R.J.
aDepartment of Biological Sciences, Florida International University, Miami, Fla., and bDepartment of Genetics, Stanford University, Stanford, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/12/2005
Accepted: 3/23/2006
Published online: 8/16/2006

Number of Print Pages: 12
Number of Figures: 5
Number of Tables: 3

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE

Abstract

Due to its pivotal geographic position, present day Iran likely served as a gateway of reciprocal human movements. However, the extent to which the deserts within the Iranian plateau and the mountain ranges surrounding Persia inhibited gene flow via this corridor remains uncertain. In order to assess the magnitude of this region’s role as a nexus for Africa, Asia and Europe in human migrations, high-resolution Y-chromosome analyses were performed on 150 Iranian males. Haplogroup data were subsequently compared to regional populations characterized at similar phylogenetic levels. The Iranians display considerable haplogroup diversity consistent with patterns observed in populations of the Middle East overall, reinforcing the notion of Persia as a venue for human disseminations. Admixture analyses of geographically targeted, regional populations along the latitudinal corridor spanning from Anatolia to the Indus Valley demonstrated contributions to Persia from both the east and west. However, significant differences were uncovered upon stratification of the gene donors, including higher proportions from central east and southeast Turkey as compared to Pakistan. In addition to the modulating effects of geographic obstacles, culturally mediated amalgamations consistent with the diverse spectrum of a variety of historical empires may account for the distribution of haplogroups and lineages observed. Our study of high-resolution Y-chromosome genotyping allowed for an in-depth analysis unattained in previous studies of the area, revealing important migratory and demographic events that shaped the contemporary genetic landscape.


  

Author Contacts

Dr. Rene J. Herrera
Department of Biological Sciences, Florida International University
University Park, OE 304
Miami, FL 33199 (USA)
Tel. +1 305 348 1258, Fax +1 305 348 1259, E-Mail herrerar@fiu.edu

  

Article Information

M. Regueiro and A.M. Cadenas contributed equally to the article.

Received: December 12, 2005
Accepted: March 23, 2006
Published online: June 12, 2006
Number of Print Pages : 12
Number of Figures : 5, Number of Tables : 3, Number of References : 39

  

Publication Details

Human Heredity (International Journal of Human and Medical Genetics)

Vol. 61, No. 3, Year 2006 (Cover Date: August 2006)

Journal Editor: Devoto, M. (Philadelphia, Pa.)
ISSN: 0001–5652 (print), 1423–0062 (Online)

For additional information: http://www.karger.com/HHE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/12/2005
Accepted: 3/23/2006
Published online: 8/16/2006

Number of Print Pages: 12
Number of Figures: 5
Number of Tables: 3

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE


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