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Table of Contents
Vol. 28, No. 4-5, 2006
Issue release date: August 2006
Section title: Overview
Dev Neurosci 2006;28:244–255
(DOI:10.1159/000094151)

Pediatric Traumatic Brain Injury: Quo Vadis?

Kochanek P.M.
Departments of Critical Care Medicine, Anesthesiology and Pediatrics, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pa., USA

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Article / Publication Details

First-Page Preview
Abstract of Overview

Published online: 8/28/2006

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

Abstract

In this review, five questions serve as the framework to discuss the importance of age-related differences in the pathophysiology and therapy of traumatic brain injury (TBI). The following questions are included: (1) Is diffuse cerebral swelling an important feature of pediatric TBI and what is its etiology? (2) Is the developing brain more vulnerable than the adult brain to apoptotic neuronal death after TBI and, if so, what are the clinical implications? (3) If the developing brain has enhanced plasticity versus the adult brain, why are outcomes so poor in infants and young children with severe TBI? (4) What contributes to the poor outcomes in the special case of inflicted childhood neurotrauma and how do we limit it? (5) Should both therapeutic targets and treatments of pediatric TBI be unique? Strong support is presented for the existence of unique biochemical, molecular, cellular and physiological facets of TBI in infants and children versus adults. Unique therapeutic targets and enhanced therapeutic opportunities, both in the acute phase after injury and in rehabilitation and regeneration, are suggested.


  

Author Contacts

Dr. Patrick M. Kochanek
University of Pittsburgh
School of Medicine, Safar Center for Resuscitation Research
Pittsburgh, PA 15260 (USA)
Tel. +1 412 383 1900, Fax +1 412 624 0943, E-Mail kochanekpm@ccm.upmc.edu

  

Article Information

Received: December 14, 2005
Accepted: February 24, 2006
Number of Print Pages : 12
Number of Figures : 0, Number of Tables : 0, Number of References : 127

  

Publication Details

Developmental Neuroscience

Vol. 28, No. 4-5, Year 2006 (Cover Date: August 2006)

Journal Editor: Campagnoni, A.T. (Los Angeles, Calif.)
ISSN: 0378–5866 (print), 1421–9859 (Online)

For additional information: http://www.karger.com/DNE


Article / Publication Details

First-Page Preview
Abstract of Overview

Published online: 8/28/2006

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE


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