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Clinical Research

Serum Biomarkers after Traumatic and Hypoxemic Brain Injuries: Insight into the Biochemical Response of the Pediatric Brain to Inflicted Brain Injury

Pardes Berger R.a, b · Adelson P.D.c · Richichi R.e · Kochanek P.M.b, d

Author affiliations

aDepartment of Pediatrics, Child Advocacy Center, Children’s Hospital of Pittsburgh, bSafar Center for Resuscitation Research, University of Pittsburgh, cDepartment of Neurosurgery, Children’s Hospital of Pittsburgh, University of Pittsburgh, dDepartment of Critical Care Medicine, Children’s Hospital of Pittsburgh, Pittsburgh, Pa., and eStatistical Analysis and Measurement Consultants, Inc., Lanexa, Va., USA

Related Articles for ""

Dev Neurosci 2006;28:327–335

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Article / Publication Details

First-Page Preview
Abstract of Clinical Research

Published online: August 28, 2006
Issue release date: August 2006

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 1

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

Abstract

Inflicted traumatic brain injury (iTBI) involves a combination of mechanical trauma and hypoxemia. Serum biomarker concentrations may provide objective information about their relative importance to the pathophysiology of iTBI. We compared the time course of neuron-specific enolase (NSE), S100B and myelin basic protein after pediatric hypoxic-ischemic brain injury, iTBI and noninflicted TBI (nTBI). The time to reach peak concentrations of all three biomarkers was shorter after nTBI. Initial and peak S100B, initial and peak myelin basic protein and peak NSE concentrations were no different between the three groups. Initial NSE concentration was highest after nTBI. These results suggest that the biochemical response of the brain to iTBI is distinct from the response to nTBI and shares temporal similarities with hypoxic-ischemic brain injury. This may have important implications for the treatment and prognosis of children with iTBI.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Research

Published online: August 28, 2006
Issue release date: August 2006

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 1

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE


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