Large animal models have been used much less frequently than rodent models to study traumatic brain injury. However, large animal models offer distinct advantages in replicating specific mechanisms, morphology and maturational stages relevant to age-dependent injury responses. This paper reviews how each of these features is relevant in matching a model to a particular scientific question and discusses various scaling strategies, advantages and disadvantages of large animal models for studying traumatic brain injury in infants and children. Progress to date and future directions are outlined.
Ann-Christine Duhaime, MD
Pediatric Neurosurgery, Children’s Hospital at Dartmouth
Dartmouth Hitchcock Medical Center, 1 Medical Center Drive
Lebanon, NH 03756 (USA)
Tel. +1 603 653 9880, Fax +1 603 650 0908, E-Mail firstname.lastname@example.org
Received: December 14, 2005
Accepted: May 9, 2006
Number of Print Pages : 8
Number of Figures : 0, Number of Tables : 1, Number of References : 64
Vol. 28, No. 4-5, Year 2006 (Cover Date: August 2006)
Journal Editor: Campagnoni, A.T. (Los Angeles, Calif.)
ISSN: 0378–5866 (print), 1421–9859 (Online)
For additional information: http://www.karger.com/DNE
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