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Techniques

Multiplex-FISH (M-FISH): technique, developments and applications

Kearney L.

Author affiliations

Section of Haemato-Oncology, Institute of Cancer Research, London (UK)

Related Articles for ""

Cytogenet Genome Res 114:189–198 (2006)

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Article / Publication Details

First-Page Preview
Abstract of Techniques

Published online: September 01, 2006
Issue release date: August 2006

Number of Print Pages: 10
Number of Figures: 4
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Multiplex FISH (M-FISH) represents one of the most significant developments in molecular cytogenetics of the past decade. Originally designed to generate 24 colour karyotyping, the technique has spawned many variations and an equally diverse range of applications. In tumour and leukaemia cytogenetics, the two groups that have been targeted represent both ends of the cytogenetic spectrum: those with an apparently normal karyotype (suspected of harbouring small rearrangements not detectable by conventional cytogenetics) and those with a complex aberrant karyotype (which are difficult to karyotype accurately due to the sheer number of aberrations). In research, mouse M-FISH provides a powerful tool to characterize mouse models of a disease. In addition, the ability to accurately karyotype single metaphases without selection makes M-FISH the perfect tool in chromosome breakage studies and for characterizing clonal evolution of tumours. Finally, M-FISH has emerged as the perfect partner for the developing genomic microarray (array CGH) technologies, providing a powerful approach to gene discovery.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Techniques

Published online: September 01, 2006
Issue release date: August 2006

Number of Print Pages: 10
Number of Figures: 4
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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