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Vol. 56, No. 1, 2006
Issue release date: September 2006
Section title: Original Paper
Eur Neurol 2006;56:1–5
(DOI:10.1159/000094248)

Facioscapulohumeral Muscular Dystrophy and Occurrence of Heart Arrhythmia

Trevisan C.P. · Pastorello E. · Armani M. · Angelini C. · Nante G. · Tomelleri G. · Tonin P. · Mongini T. · Palmucci L. · Galluzzi G. · Tupler R.G. · Barchitta A.
aDepartment of Neurosciences and bDepartment of Internal Medicine, University of Padua, Padua, cDepartment of Neurological Sciences and Vision, University of Verona, Verona, dDepartment of Neuroscience, University of Torino, Torino, eInstitute of Neurology, Catholic University, Policlinico Gemelli, Roma, and fLaboratory of Neurogenetics, University of Modena and Reggio Emilia, Modena, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/18/2006
Accepted: 3/29/2006
Published online: 9/8/2006

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 3

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Background: Subjects with facioscapulohumeral muscular dystrophy (FSHD) do not generally suffer from significant cardiac symptoms. Although with heterogeneous results, studies reported to date indicate that heart alterations unrelated to cardiomyopathy are possible in FSHD. Patients and Methods: We describe the findings of a multicenter investigation aimed at detecting cardiac abnormalities in 83 FSHD patients, 44 males and 39 females with a mean age of 47 years. All patients underwent clinical heart examination, 12-lead electrocardiography and 24-hour Holter monitoring; echocardiography was also performed on most patients. Results: Among the 83 patients, 62 with no cardiovascular risk factors were identified. Ten of them manifested clinical or subclinical cardiac involvement: 5 reported symptoms represented mostly by frequent palpitations secondary to supraventricular arrhythmia and another 5 exhibited electrocardiographic signs of short runs of supraventricular paroxysmal tachycardia. In the absence of cardiovascular risk factors, we found symptoms or signs of heart involvement of mainly arrhythmic origin in 10 of our 83 FSHD patients (12%). Conclusions: Considering our data and those available in the literature as a whole, arrhythmic alterations seem to be detected more frequently than expected in FSHD patients.


  

Author Contacts

Prof. C.P. Trevisan, MD
Università di Padova, Clinica Neurologica II – Osp. S. Antonio
Via Facciolati, 71
IT–35127 Padova (Italy)
Tel. +39 049 821 5315, Fax +39 049 821 5316, E-Mail carlopietro.trevisan@unipd.it

  

Article Information

Received: January 18, 2006
Accepted: March 29, 2006
Published online: June 27, 2006
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 3, Number of References : 22

  

Publication Details

European Neurology

Vol. 56, No. 1, Year 2006 (Cover Date: September 2006)

Journal Editor: Bogousslavsky, J. (Lausanne)
ISSN: 0014–3022 (print), 1421–9913 (Online)

For additional information: http://www.karger.com/ENE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/18/2006
Accepted: 3/29/2006
Published online: 9/8/2006

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 3

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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