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Vol. 43, No. 4, 2006
Issue release date: July 2006
Section title: Short Communication
J Vasc Res 2006;43:377–382
(DOI:10.1159/000094258)

Expression of IL-1β, IL-1 Receptor Type I and IL-1 Receptor Antagonist in Human Aortic Smooth Muscle Cells: Effects of all-trans-Retinoic Acid

Wågsäter D. · Jatta K. · Ocaya P. · Dimberg J. · Sirsjö A.
aDivision of Biomedicine, Department of Clinical Medicine, University of Örebro, Örebro, and bDepartment of Natural Science and Biomedicine, University College of Health Sciences, Jönköping, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: 10/21/2005
Accepted: 5/3/2006
Published online: 7/28/2006

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 0

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR

Abstract

The proinflammatory cytokine interleukin (IL)-1β and the IL-1 receptor antagonist are expressed by atherosclerotic plaques and may be linked to the development of atherosclerosis. Existing evidence shows that retinoids and their receptors are involved in inflammatory response and that they are found in atherosclerotic plaques. In all-trans-retinoic acid (atRA)-treated human aortic smooth muscle cells (AOSMC), significant increases in IL-1β levels were observed, compared with untreated cells. Examination of IL-1 receptor antagonist and IL-1 receptor type I levels did not show any difference between atRA-treated and -untreated AOSMC. The results show that atRA-treated AOSMC express both the precursor (33 kDa) and the active form (17 kDa) of the IL-1β protein. atRA-treated carotid lesions showed significantly elevated IL-1β mRNA levels (2.9 ± 2.33) compared with untreated lesions (2.0 ± 1.77; p < 0.05). These results support the role of atRA as a regulator of inflammation such as in atherosclerosis.


  

Author Contacts

Dr. Ken Jatta
Division of Biomedicine, Department of Clinical Medicine
University of Örebro
SE–701 82 Örebro (Sweden)
Tel. +46 73648 3877, Fax +46 1930 3778, E-Mail ken.jatta@ikm.oru.se

  

Article Information

D.W. and K.J. contributed equally to this article.

Received: October 21, 2005
Accepted after revision: May 3, 2006
Published online: June 28, 2006
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 0, Number of References : 34

  

Publication Details

Journal of Vascular Research (Incorporating 'International Journal of Microcirculation')

Vol. 43, No. 4, Year 2006 (Cover Date: July 2006)

Journal Editor: Pohl, U. (Munich)
ISSN: 1018–1172 (print), 1423–0135 (Online)

For additional information: http://www.karger.com/JVR


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: 10/21/2005
Accepted: 5/3/2006
Published online: 7/28/2006

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 0

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR


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