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Vol. 66, No. 4, 2006
Issue release date: September 2006
Section title: Original Paper
Horm Res 2006;66:182–188
(DOI:10.1159/000094467)

A Clinical and Laboratory Evaluation of Methionine Cycle-Transsulfuration and Androgen Pathway Markers in Children with Autistic Disorders

Geier D.A. · Geier M.R.
aPresident, MedCon, Inc., 14 Redgate Ct., Silver Spring, MD 20905, USA, Tel. +1 301 384 6988, E-Mail DavidAllenGeier@comcast.net, and bPresident, The Genetic Centers of America, 14 Redgate Ct., Silver Spring, MD 20905, USA, Tel. +1 301 989 0548, Fax +1 301 989 1543, E-Mail mgeier@comcast.net

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 9/20/2006

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Background/Aims: The prevalence of autism spectrum disorders (ASDs) is 1 in 300 children in the US. ASDs are characterized by impairments in social relatedness and communication, repetitive behaviors, abnormal movement patterns, and sensory dysfunction. Pre-pubertal age children with ASDs were assessed for metabolites in the methionine cycle-transsulfuration and androgen pathways, and for present physical development/behaviors indicative of hyperandrogenicity. Methods: The Institutional Review Board of the Institute for Chronic Illnesses (Office for Human Research Protections, US Department of Health and Human Services IRB number: IRB00005375) approved the present study. Sixteen consecutive pre-pubertal age children (≤11 years old; mean ± SD: 5.9 ± 2.1 years old) with previously diagnosed ASDs that presented to the Genetic Centers of America for outpatient care were evaluated. Results: Significantly (p < 0.01) increased levels of serum/plasma dehydroepiandrosterone and serum total testosterone relative to the age- and sex-specific normal laboratory reference ranges were observed. Conversely, serum follicle-stimulating hormone levels were significantly (p < 0.01) decreased. Plasma-reduced glutathione (p < 0.01), plasma cysteine (p < 0.01), plasma methionine (p < 0.01), serum cystathionine (p < 0.05), and serum homocysteine (p < 0.01) were all significantly decreased. Conclusion: The results suggest a possible cyclical interaction between the methionine cycle-transsulfuration and androgen pathways in some children with ASDs.


  

Author Contacts

Mark R. Geier, MD, PhD
President, The Genetic Centers of America
14 Redgate Ct.
Silver Spring, MD 20905 (USA)
Tel. +1 301 989 0548, Fax +1 301 989 1543, E-Mail mgeier@comcast.net

  

Article Information

Potential conflict of interest and affiliation statement: Dr. Mark Geier is not affiliated with MedCon, Inc. David Geier is the President of MedCon. MedCon does not have a financial interest in relation to autism and puberty. Neither Dr. Mark Geier nor David Geier has any conflict of interest regarding anything related to this paper.

Received: December 9, 2005
Accepted: March 23, 2006
Published online: July 5, 2006
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 18

  

Publication Details

Hormone Research (From Developmental Endocrinology to Clinical Research)

Vol. 66, No. 4, Year 2006 (Cover Date: September 2006)

Journal Editor: Czernichow, P. (Paris)
ISSN: 0301–0163 (print), 1423–0046 (Online)

For additional information: http://www.karger.com/HRE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 9/20/2006

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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