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Table of Contents
Vol. 141, No. 2, 2006
Issue release date: September 2006
Section title: Original Paper
Int Arch Allergy Immunol 2006;141:110–118
(DOI:10.1159/000094713)

The Major Allergen of Olive Pollen Ole e 1 Is a Diagnostic Marker for Sensitization to Oleaceae

Palomares O.a · Swoboda I.b, c · Villalba M.a · Balic N.b · Spitzauer S.b · Rodríguez R.a · Valenta R.c
aDepartamento de Bioquímica y Biología Molecular, Facultad de Química, Universidad Complutense de Madrid, Madrid, Spain; bInstitute of Medical and Chemical Laboratory Diagnostics and cDivision of Immunopathology, Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 07, 2005
Accepted: March 30, 2006
Published online: September 20, 2006
Issue release date: September 2006

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Trees of the family Oleaceae are important allergen sources, with a strongly varying geographic distribution. For example, olive pollen is an important allergen source in Mediterranean countries, whereas ash pollen dominates in Northern and Central Europe and North America. The aim of this study was to compare the profiles of olive and ash pollen allergens and to study the degree of cross-reactivity using populations of allergic patients selectively exposed to olive or ash pollen. Methods: Olive and ash pollen extracts were analyzed by IgE immunoblotting using sera from Spanish patients highly exposed to olive pollen and Austrian patients without olive but ash pollen exposure. IgE cross-reactivity was studied by qualitative immunoblot inhibition assays and semiquantitative ELISA inhibitions using olive, ash, birch, mugwort, timothy grass pollen extracts and the major olive pollen allergen, Ole e 1. Results: Spanish and Austrian patients exhibited an almost identical IgE-binding profile to olive and ash pollen allergens, with major reactivity directed against Ole e 1, and its homologous ash counterpart, Fra e 1. IgE inhibition experiments demonstrated extensive cross-reactivity between olive and ash pollen allergens. However, whereas cross-reactions between profilins and calcium-binding allergens also occurred between unrelated plant species, cross-reactivity to Ole e 1 was confined to plants belonging to the Oleaceae. Conclusions: Ole e 1 is a marker allergen for the diagnosis of olive and ash pollen allergy.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 07, 2005
Accepted: March 30, 2006
Published online: September 20, 2006
Issue release date: September 2006

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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