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Vol. 77, No. 3, 2006
Issue release date: October 2006
Section title: Original Paper
Urol Int 2006;77:269–274
(DOI:10.1159/000094821)

Pumpkin Seed Oil and Phytosterol-F Can Block Testosterone/Prazosin-Induced Prostate Growth in Rats

Tsai Y.-S. · Tong Y.-C. · Cheng J.-T. · Lee C.-H. · Yang F.-S. · Lee H.-Y.
aInstitute of Clinical Medicine and Departments of bUrology and cPharmacology, College of Medicine, National Cheng Kung University, and dCentral R & D Institute, Uni-President Enterprises Corp., Tainan, Taiwan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/30/2005
Accepted: 12/21/2005
Published online: 10/11/2006

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Introduction: This study was undertaken to investigate the effects of pumpkin seed oil alone or combined with Phytosterol-F on testosterone/prazosin-induced (T-P) prostate growth in rats. Materials and Methods: Forty adult Wistar rats were divided into five groups, including: one control group, rats treated with vehicle only, one group treated with T-P, and two groups of T-P-treated rats, one receiving orally pumpkin seed oil alone and one group receiving orally pumpkin seed oil combined with Phytosterol-F. Two weeks later, the prostatic weight-to-body weight ratio was determined after sacrifice. The total protein concentration was measured by using a protein assay. Some ventral prostatic tissues were histologically examined after hematoxylin-eosin staining. Results: Histological sections of the ventral prostate showed that the architecture of the prostate glands became hyperplastic in the T-P rats, but not in the control or vehicle-treated animals. As compared with the control or vehicle group, T-P rats had a significantly higher prostatic weight-to-body weight ratio for the ventral prostate (p = 0.05 and p = 0.007, respectively), but not for the dorsolateral prostate (p = 0.53 and p = 0.73, respectively). The T-P rats had significantly higher protein levels within both lobes (ventral lobe, p = 0.02 and p < 0.0001, respectively; dorsolateral lobe, p = 0.06 and p = 0.005, respectively). As compared with the T-P-alone rats, the TP rats treated with pumpkin seed oil alone or pumpkin seed oil combined with Phytosterol-F had a significantly lower weight ratio for the ventral prostate (p = 0.01 and p = 0.004, respectively) and significantly lower protein levels within both lobes (p = 0.03 and p = 0.003, respectively; p = 0.007 and p = 0.002, respectively). In addition, Phytosterol-F had some additive effect on the total protein synthesis within the ventral prostate (p = 0.02). Conclusion: Pumpkin seed oil alone or combined with Phytosterol-F can block the T-P-induced increases in prostatic weight-to-body weight ratio and protein synthesis.


  

Author Contacts

Prof. Yat-Ching Tong
Department of Urology, College of Medicine
National Cheng Kung University, 138 Shengli Road
Tainan 701 (Taiwan)
Tel. +886 6 235 3535, ext. 5251, Fax +886 6 238 3678, E-Mail yctong@mail.ncku.edu.tw

  

Article Information

Received: August 30, 2005
Revised and accepted: December 21, 2005
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 0, Number of References : 23

  

Publication Details

Urologia Internationalis

Vol. 77, No. 3, Year 2006 (Cover Date: October 2006)

Journal Editor: Hakenberg, O.W. (Dresden)
ISSN: 0042–1138 (print), 1423–0399 (Online)

For additional information: http://www.karger.com/UIN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/30/2005
Accepted: 12/21/2005
Published online: 10/11/2006

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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