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Beta-Amlyoid 1–42 and Tau-Protein in Cerebrospinal Fluid of Patients with Parkinson’s Disease DementiaMollenhauer B.a, g · Trenkwalder C.d, e · von Ahsen N.b · Bibl M.c · Steinacker P.a, h · Brechlin P.a · Schindehuette J.d · Poser S.a · Wiltfang J.f · Otto M.a, c, h
Departments of aNeurology, bClinical Chemistry, cPsychiatry and dClinical Neurophysiology, Georg-August University, eParacelsus-Elena Clinic, Kassel, and fDepartment of Psychiatry, Friedrich-Alexander University, Erlangen/Nuremberg, Germany; gCenter for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass., USA; hDepartment of Neurology, University of Ulm, Ulm, Germany
Measurement of τ-protein and β-amyloid1–42 (Aβ42) in cerebrospinal fluid (CSF) has gained increasing acceptance in the differential diagnosis of Alzheimer’s disease. We investigated CSF τ-protein and Aβ42 concentrations in 73 patients with advanced idiopathic Parkinson’s disease with dementia (PDD) and 23 patients with idiopathic Parkinson’s disease without dementia (PD) and in a comparison group of 41 non-demented neurological patients (CG) using commercially available enzyme-linked-immunoabsorbant-assay (ELISA). τ-Protein levels were statistically significantly higher and Aβ42 lower in the PDD patients compared to PD patients and the CG. This observation was most marked (p < 0.05) in a subgroup of patients with PDD carrying the apolipoprotein genotype ε3/ε3. The distribution of the apolipoprotein genotypes in PDD and PD patients was similar to that of the CG. Although a significant difference in τ-protein values was observed between PDD and CG, no diagnostic cut-off value was established. These findings suggest that such protein CSF changes may help to support the clinical diagnosis of cognitive decline in PD and that there may be apolipoprotein-E-isoform-specific differences in CSF protein regulation in advanced PDD.
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