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Table of Contents
Vol. 61, No. 4, 2006
Issue release date: September 2006
Section title: Original Paper
Hum Hered 2006;61:237–243
(DOI:10.1159/000095216)

Identification of Two Sex-Specific Quantitative Trait Loci in Chromosome 11q for Hip Bone Mineral Density in Chinese

Huang Q.-Y.a · Ng M.Y.M.a · Cheung C.-L.a · Chan V.a · Sham P.-C.b · Kung A.W.C.a
aDepartment of Medicine and bGenome Research Center, The University of Hong Kong, Hong Kong, SAR, China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 17, 2006
Accepted: June 07, 2006
Published online: September 08, 2006
Issue release date: September 2006

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 1

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE

Abstract

Background: Chromosome 11q has not only been found to contain mutations responsible for the several Mendelian disorders of the skeleton, but it has also been linked to bone mineral density (BMD) variation in several genome-wide linkage studies. Furthermore, quantitative trait loci (QTL) affecting BMD in inbred mice and baboons have been mapped to a region syntenic to human chromosome 11q. The aim of the present study is to determine whether there is a QTL for BMD variation on chromosome 11q in the Chinese population. Methods: Nineteen microsatellite markers were genotyped for a 75 cM region on 11q13-25 in 306 Chinese families with 1,459 subjects. BMD (g/cm2) was measured by DXA. Linkage analyses were performed using the variance component linkage analysis method implemented in Merlin software. Results: For women, a maximum LOD score of 1.62 was achieved at 90.8 cM on 11q21 near the marker D11S4175 for femoral neck BMD; LOD scores greater than 1.0 were observed on 11q13 for trochanter BMD. For men, a maximum LOD score of 1.57 was achieved at 135.8 cM on 11q24 near the marker D11S4126 for total hip BMD. Conclusion: We have not only replicated the previous linkage finding on chromosome 11q but also identified two sex-specific QTL that contribute to BMD variation in Chinese women and men.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 17, 2006
Accepted: June 07, 2006
Published online: September 08, 2006
Issue release date: September 2006

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 1

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE


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