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Original Article · Originalarbeit

Effects of Potentised Substances on Growth Kinetics of Saccharomyces cerevisiae and Schizosaccharomyces pombe

Scherr C.a,c · Baumgartner S.a,b · Spranger J.c,e · Simon M.d

Author affiliations

aVerein für Krebsforschung, Institut Hiscia, Arlesheim, Schweiz bKollegiale Instanz für Komplementärmedizin (KIKOM), Universität Bern, Insel-Spital, Imhoof-Pavillon, Bern, Schweiz cForschungsinstitut für biologischen Landbau, Frick, Schweiz dInstitut für Chemie und Biologie des Meeres (ICBM), Universität Oldenburg, Deutschland eInstitut für anthroposophische Veterinärmedizin, Frick, Schweiz

Related Articles for ""

Forsch Komplementärmed 2006;13:298-306

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Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: October 20, 2006
Issue release date: October 2006

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 2504-2092 (Print)
eISSN: 2504-2106 (Online)

For additional information: http://www.karger.com/CMR

Abstract

Homeopathic potencies are used as specific remedies in complementary medicine. Since the mode of action is unknown, the presumed specificity is discussed controversially. Objective: This study investigated the effects of potentised substances on two yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe, in a stable and reliable test system with systematic negative controls. Materials and Methods: Yeast cells were cultivated in either potentised substances or water controls in microplates and their growth kinetics were measured photometrically. Water control runs were performed repeatedly to investigate the stability of the experimental set-up (systematic negative controls). Results: 4 out of 14 screened substances seem to have affected the growth curve parameters slope or yield. Out of these substances, azoxystrobin and phosphorus were chosen for 8 further replication experiments, which partly confirmed the results of the screening. On the average of all experiments, azoxystrobin affected the slope of the growth curve of Saccharomyces cerevisiae (p < 0.05), and phosphorus affected the slope of the growth curve of Schizosaccharomyces pombe (p < 0.05). No effects were seen in the water control runs. In addition, significant interactions between treatment with potentised substances and experiment number were observed in all experiments with potentised substances (p < 0.01), but not in the water control runs. Conclusions: Both yeast species reacted to certain potentised substances by changing their growth kinetics. However, the interactions found point to additional factors of still unknown nature, that modulate the effects of potentised substances. This stable test system with yeasts may be suitable for further studies regarding the efficacy of homeopathic potencies.


Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: October 20, 2006
Issue release date: October 2006

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 2504-2092 (Print)
eISSN: 2504-2106 (Online)

For additional information: http://www.karger.com/CMR


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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