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Vol. 63, No. 1, 2007
Issue release date: January 2007
Section title: Original Article
Gynecol Obstet Invest 2007;63:55–60
(DOI:10.1159/000095498)

A Double-Blind Randomized Controlled Trial of Oral Misoprostol and Intramuscular Syntometrine in the Management of the Third Stage of Labor

Ng P.S. · Lai C.Y. · Sahota D.S. · Yuen P.M.
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T., Hong Kong, SAR, China

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: 6/20/2005
Accepted: 6/11/2006
Published online: 8/29/2006

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 5

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Background: The aim of this study was to compare the efficacy and safety of oral misoprostol 400 µg with intramuscular syntometrine in the management of the third stage of labor. Material and Methods: This was a double-blind randomized controlled trial conducted in a tertiary care hospital. Three hundred and fifty-five women randomized to receive either oral misoprostol 400 µg or intramuscular syntometrine in the third stage of labor were studied. The change in hemoglobin level from before to 48 h after delivery, use of additional oxytocics and treatment related side effects were the main outcome measures. Results: There were no significant differences between the two groups in terms of the change in hemoglobin level and mean blood loss. The incidence of shivering was significantly higher in the misoprostol group whilst that of vomiting was significantly higher in the syntometrine group. There were no differences in the incidence of nausea, headache, diarrhea and pyrexia between the two groups. Conclusion: Orally administeredmisoprostol at a dose of 400 µg is an acceptable alternative in preventing post-partum blood loss, as measured by the peri-partum change in hemoglobin level and was not associated with an increased incidence of side effects.


  

Author Contacts

Dr. P.M. Yuen
Departments of Obstetrics and Gynaecology
Prince of Wales Hospital
Shatin, N.T., Hong Kong, SAR (China)
Tel. +852 2632 2810, Fax +852 2636 0008, E-Mail pmyuen@cuhk.edu.hk

  

Article Information

Received: June 20, 2005
Accepted: June 11, 2006
Published online: August 29, 2006
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 5, Number of References : 16

  

Publication Details

Gynecologic and Obstetric Investigation

Vol. 63, No. 1, Year 2007 (Cover Date: January 2007)

Journal Editor: D'Hooghe, T. (Leuven)
ISSN: 0378–7346 (print), 1423–002X (Online)

For additional information: http://www.karger.com/GOI


Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: 6/20/2005
Accepted: 6/11/2006
Published online: 8/29/2006

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 5

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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