Effect of Reproductive Factors and Postmenopausal Hormone Use on the Risk of Amyotrophic Lateral SclerosisPopat R.A. · Van Den Eeden S.K. · Tanner C.M. · Bernstein A.L. · Bloch D.A. · Leimpeter A. · McGuire V. · Nelson L.M.
aDepartment of Health Research and Policy, Division of Epidemiology, Stanford University School of Medicine, Stanford, Calif., bKaiser Permanente, Oakland, Calif., cThe Parkinson’s Institute, Sunnyvale, Calif., and dKaiser Santa Rosa Medical Center, Santa Rosa, Calif., USA
Objective: To examine the associations of reproductive factors and postmenopausal hormone use with the risk of amyotrophic lateral sclerosis (ALS) among women. Methods: This case-control study was conducted within the Kaiser Permanente Medical Care Program (KPMCP) of Northern California during the years 1996–2000. Among the 193 postmenopausal women, 62 were incident ALS cases and 131 were controls randomly selected from KPMCP members and frequency matched by age and respondent type (self versus proxy) to the cases. Statistical analyses were carried out using logistic regression. Results: Reproductive factors such as age at menarche, age at final menstrual period, parity, oral contraceptive use, and type of menopause (natural vs. hysterectomy with or without oophorectomy) were not associated with risk of ALS. Postmenopausal hormone use was positively, but not significantly, associated with the risk of ALS (adjusted OR 1.9, 95% CI 0.9–3.8). Conclusions: Reproductive factors were not associated with ALS risk. There is no evidence that suggests a protective effect of postmenopausal hormone use against the development of ALS. However, due to insufficient power, we cannot rule out a possible increase in ALS risk associated with postmenopausal hormone use.
Rita A. Popat, PhD
Department of Health Research and Policy, Division of Epidemiology
HRP Redwood Building, Room T209, Stanford University School of Medicine
Stanford, CA 94305-5405 (USA)
Tel. +1 650 498 5206, Fax +1 650 725 6951, E-Mail email@example.com
Published online: August 31, 2006
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 1, Number of References : 16
Vol. 27, No. 3, Year 2006 (Cover Date: October 2006)
Journal Editor: Román, G.C. (San Antonio, Tex.)
ISSN: 0251–5350 (print), 1423–0208 (Online)
For additional information: http://www.karger.com/NED