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Vol. 21, No. 6, 2006
Issue release date: November 2006
Section title: Paper
Fetal Diagn Ther 2006;21:528–531
(DOI:10.1159/000095667)

The Effectiveness of Adrenocorticotropin Repeated Doses in High Risk Pregnancies

Klimek M.
Department of Gynecology and Infertility Clinic of Jagiellonian University, Krakow, Poland

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 7/12/2005
Accepted: 1/19/2006
Published online: 11/29/2006

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT

Abstract

Objective: The aim of this study was to assess the effect of two kinds of adrenocorticotropin (ACTH)-depot repeated doses administered to pregnant women who underwent infertility treatment. Material and Methods: The study population included 424 pregnant women with singletons. Two hundred and forty-two women received repeated 0.5 mg doses of ACTH, whereas 182 women also were treated for infertility but did not receive any therapy. The ACTH-treated patients were subdivided into two subgroups: (1) 142 patients received only series of three 0.5 g ACTH-depot injections every other day in the first and/or second trimester with occasionally single ACTH-depot doses in the third trimester, (2) 100 patients received only single 0.5 mg ACTH-depot doses for the entire duration of pregnancy. Clinical symptoms of threatened abortion and preterm delivery as well as very low or decreasing levels of serum oxytocinases were indications for the hormonal therapy. Low oxytocinase serum levels, recurrent abortion and preterm delivery characterize pregnant women with hypothalamic insufficiency. Results: Women who received only single doses of the ACTH-therapy for the entire duration of pregnancy had a statistically significant longer gestation, and higher newborn mass and length than patients who received a series of three hormonal injections as well as control women who had no clinical or laboratory indication for such therapy. Conclusions: ACTH-depot injection results in the oxytocinase increased serum level, a decreased number of abortion and preterm deliveries and prolonged duration of pregnancy. Single repeated doses of the ACTH-depot therapy had statistically significant better results in the prolongation of pregnancy, newborn mass and length than a serial hormonal dosage.


  

Author Contacts

Marek Klimek MD, PhD
Department of Gynecology and Infertility Clinic of Jagiellonian University
23 Kopernik Str
PL–31-501 Krakow (Poland)
Tel. +4812 424 8528, Fax +4812 424 8585, E-Mail mmklimek@mp.pl

  

Article Information

Received: July 12, 2005
Accepted after revision: January 19, 2006
Published online: September 12, 2006
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 2, Number of References : 25

  

Publication Details

Fetal Diagnosis and Therapy (Clinical Advances and Basic Research)

Vol. 21, No. 6, Year 2006 (Cover Date: November 2006)

Journal Editor: Holzgreve, W. (Basel)
ISSN: 1015–3837 (print), 1421–9964 (Online)

For additional information: http://www.karger.com/FDT


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 7/12/2005
Accepted: 1/19/2006
Published online: 11/29/2006

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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