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Table of Contents
Vol. 108, No. 2, 2007
Issue release date: August 2007
Section title: Original Research
Cardiology 2007;108:90–96
(DOI:10.1159/000095936)

Histologic Assessment of Right Atrial Appendage Myocardium in Patients with Atrial Fibrillation after Coronary Artery Bypass Graft Surgery

Nakai T. · Chandy J. · Nakai K. · Bellows W.H. · Flachsbart K. · Lee R.J. · Leung J.M.
aDivision of Cardiovascular Medicine, Nihon University School of Medicine, Tokyo, Japan; bSection of Cardiac Electrophysiology, Department of Medicine and Cardiovascular Research Institute, University of California, cDepartment of Anesthesia and Perioperative Care, University of California, Departments of dCardiovascular Anesthesiology, and eCardiovascular Surgery, Kaiser Permanente Medical Center, San Francisco, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 8/2/2005
Accepted: 3/7/2006
Published online: 9/28/2006

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Atrial fibrillation (AF) is a common complication after coronary artery bypass graft (CABG) surgery. Despite the prevalence of AF occurring after cardiac surgery, its pathophysiology is incompletely understood. Our previous study demonstrated that age and left atrial enlargement were independent predictors of postoperative AF. Accordingly, the purpose of this study was to determine whether cellular changes such as fibrosis and/or hypertrophy occurred in the atrium in patients who subsequently developed postoperative AF. Right atrial appendage tissue was obtained during atriotomy in patients undergoing elective CABG surgery. Quantitative assessment of atrial fibrosis was performed with Sirius red stain, and atrial cell diameter was measured with the HE stain. Linear regression, t test, χ2 test or Fisher exact test were used for statistical analysis. Sixty-one patients (mean age 71 ± 8 years) were studied. Increasing age was significantly associated with fibrosis (beta 0.3, 95% CI: 0.06–0.55, p = 0.017). The amount of right atrial fibrosis tended to correlate with the incidence of postoperative AF (p = 0.08). Cell diameter was not significantly different between patients with versus without postoperative AF (p = 0.85). These results suggest that the age-related atrial fibrosis rather than cellular hypertrophy may be important in the pathogenesis of AF after CABG surgery and should be further investigated.


  

Author Contacts

Toshiko Nakai, MD
Cardiovascular Division, Department of Medicine
University School of Medicine, 30-1 Oyaguchi Kamimachi Itabashi-ku
Tokyo 173-8610 (Japan)
Tel. +81 3 3972 8111, ext. 2413, Fax +81 3 3972 1098, E-Mail tnakai@med.nihon-u.ac.jp

  

Article Information

Received: August 2, 2005
Accepted after revision: July 3, 2006
Published online: September 28, 2006
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 2, Number of References : 33

  

Publication Details

Cardiology (International Journal of Cardiovascular Medicine, Surgery, Pathology and Pharmacology)

Vol. 108, No. 2, Year 2007 (Cover Date: August 2007)

Journal Editor: Borer, J.S. (New York, N.Y.)
ISSN: 0008–6312 (print), 1421–9751 (Online)

For additional information: http://www.karger.com/CRD


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 8/2/2005
Accepted: 3/7/2006
Published online: 9/28/2006

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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