In vitro and in vivo Antiplasmodial Activity of Momordica balsamina Alone or in a Traditional MixtureBenoit-Vical F.a, b · Grellier P.c · Abdoulaye A.e · Moussa I.e · Ousmane A.e · Berry A.b · Ikhiri K.e · Poupat C.d
aLaboratoire de Chimie de Coordination du CNRS, UPR8241, and bService de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Rangueil, Toulouse, cUSM504 Biologie fonctionnelle des protozoaires, Département Régulations, Développement, Diversité Moléculaire, Muséum National d’Histoire Naturelle, Paris, and dInstitut de Chimie des Substances Naturelles du CNRS, Gif-sur-Yvette, France; eDépartement de Chimie, Faculté des Sciences, Université A. Moumouni, Niamey, Niger
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Article / Publication Details
Background: Because of the dramatic situation of malaria in Africa, there is an urgent need to find new and cheap drugs, such as herbal medicines. Here we report the study of the in vitro and in vivo antimalarial activity of Momordica balsamina alone or in a traditional mixture used in Niger. Methods: Extracts were obtained with different solvents and tested in vitro on Plasmodium falciparum and in vivo on Plasmodium vinckei. Results: The best extracts are methanolic and present promising results in vivo by intraperitoneal and oral administration. Conclusion: The antimalarial activity of M. balsamina, traditionally used in Niger, is confirmed in vitro and in vivo without any toxicity in healthy mice.
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