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Original Paper

Free Access

Diversity of Lactobacilli in the Oral Cavities of Young Women with Dental Caries

Caufield P.W. · Li Y. · Dasanayake A. · Saxena D.

Author affiliations

College of Dentistry, New York University, New York, N.Y., USA

Corresponding Author

P.W. Caufield, DDS, PhD

New York University, College of Dentistry

345 E. 24th Street, Room 1024, Kriser Building

New York, NY 10010 (USA)

Tel. +1 212 998 9603, Fax +1 212 995 3994, E-Mail pwc2@nyu.edu

Related Articles for ""

Caries Res 2007;41:2–8

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For nearly a century, lactobacilli (LB) in the oral cavity have been generally associated with dental caries. Here, we characterized the LB isolated from the saliva of 6 women with active caries using genetic-based taxonomical identification methods. From each subject, 30 isolates growing on Rogosa medium and presumed to be LB were analyzed. Of the 180 isolates, 176 were further characterized by biotyping, DNA melting points, DNA chromosomal fingerprinting, genotyping, and phylogenetic cluster assessment. We found a total of 30 unique genotypes of LB in the saliva of caries-active women, with each woman harboring between 2 and 8 distinct genotypes. Although Lactobacillus vaginalis, L. fermentum, and L. salivarius were found in 4 of 6 of the subjects, results from other studies using comparable methods show an entirely different array of LB associated with caries. These collective observations lead us to surmise that LB associated with dental caries are likely exogenous and opportunistic colonizers, arising from food or other reservoirs outside the oral cavity.

© 2007 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 15, 2005
Accepted: March 23, 2006
Published online: December 13, 2006
Issue release date: December 2006

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 0

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE

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