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Vol. 43, No. 6, 2006
Issue release date: November 2006
Section title: Research Paper
J Vasc Res 2006;43:602–610
(DOI:10.1159/000096247)

Alterations in the Lipid Metabolism of Rat Aorta: Effects of Vitamin A Deficiency

Gatica L.V. · Vega V.A. · Zirulnik F. · Oliveros L.B. · Gimenez M.S.
Department of Biochemistry and Biological Sciences, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, San Luis, Argentina

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Article / Publication Details

First-Page Preview
Abstract of Research Paper

Received: 11/24/2005
Accepted: 8/5/2006
Published online: 11/3/2006

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 3

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR

Abstract

Antioxidants are known to reduce cardiovascular disease by reducing the concentration of free radicals in the vessel wall and by preventing the oxidative modification of low-density lipoproteins. The prooxidative effect of a vitamin-A-deficient diet on the aorta has previously been demonstrated by us. In this study, the lipid metabolism in the aorta of rats fed on a vitamin-A-deficient diet was evaluated. Vitamin A deficiency induced a hypolipidemic effect (lower serum triglyceride and cholesterol levels) and a decreased serum paraoxonase 1/arylesterase activity. The concentrations of triglycerides, total cholesterol, free and esterified cholesterol, and phospholipids were increased in the aorta of vitamin-A-deficient rats. The phospholipid compositions showed an increase in phosphatidylcholine (PC), phosphatidylinositol plus phosphatidylserine and phosphatidylethanolamine, a decrease in sphingomyelin, and no change in phosphatidylglycerol. In the aorta, the increase in triglycerides was associated with an increased fatty acid synthesis and mRNA expression of diacylglycerol acyltransferase 1. The increased PC content was attributed to an increased synthesis, as measured by [methyl-14C]choline incorporation into PC and high CTP:phosphocholine cytidylyltransferase-α mRNA expression. The cholesterol synthesis, evaluated by [1-14C]acetate incorporated into cholesterol and mRNA expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase, did not change. The lipoprotein lipase and lectin-like oxidized low-density lipoprotein receptor 1 mRNA expression levels increased in the aorta of vitamin-A-deficient animals. The incorporation of vitamin A into the diet of vitamin-A-deficient rats reverted all the changes observed. These results indicate that a vitamin-A-deficient diet,in addition to having a prooxidative effect, alters the aorta lipid metabolism.


  

Author Contacts

Prof. María Sofía Gimenez
Department of Biochemistry and Biological Sciences, Chacabuco 917
National University of San Luis, 5700 San Luis (Argentina)
Tel. +54 2652 423 789, ext 152/126, Fax +54 2652 431 301
E-Mail mgimenez@unsl.edu.ar

  

Article Information

Received: November 24, 2005
Accepted after revision: August 5, 2006
Published online: October 13, 2006
Number of Print Pages : 9
Number of Figures : 3, Number of Tables : 3, Number of References : 42

  

Publication Details

Journal of Vascular Research (Incorporating 'International Journal of Microcirculation')

Vol. 43, No. 6, Year 2006 (Cover Date: November 2006)

Journal Editor: Pohl, U. (Munich)
ISSN: 1018–1172 (print), 1423–0135 (Online)

For additional information: http://www.karger.com/JVR


Article / Publication Details

First-Page Preview
Abstract of Research Paper

Received: 11/24/2005
Accepted: 8/5/2006
Published online: 11/3/2006

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 3

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR


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