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Table of Contents
Vol. 50, No. 1, 2007
Issue release date: December 2006
Section title: Original Paper
Intervirology 2007;50:24–31
(DOI:10.1159/000096309)

Clinical Characteristics of NonBNonC- HCC: Comparison with HBV and HCV Related HCC

Hatanaka K.a · Kudo M.a · Fukunaga T.a · Ueshima K.a · Chung H.a · Minami Y.a · Sakaguchi Y.a · Hagiwara S.a · Orino A.b · Osaki Y.c
Departments of Gastroenterology and Hepatology,aKinki University School of Medicine, bKobe City General Hospital, and cOsaka Red Cross Hospital, Osaka, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 11/24/2006
Issue release date: December 2006

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 2

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT

Abstract

Objective: To clarify the frequency and trends of both HBsAg and HCVAb negative hepatocellular carcinoma (NonBNonC-HCC) in all HCC, to clarify the etiology of NonBNonC-HCC, and to elucidate the clinical characteristics of NonBNonC-HCC compared with those of HBsAg-positive HCC (B-HCC) and HCVAb-positive HCC (C-HCC). Methods: A total of 2,542 patients with HCC examined at three institutions between 1991 and 2004 were categorized based on their serum viral antigen/antibody positivities, and compared between groups for the etiology, annual trend of the incidence, and clinical characteristics. Results: For the etiology, C-HCC was most prevalent, followed by B-HCC, NonBNonC-HCC, and both HBsAg and HCVAb-positive HCC (BC-HCC) in order. For survival, C-HCC had the most favorable prognosis, followed by NonBNonC-HCC, and B-HCC patients had the poorest prognosis in the three groups (C-HCC, B-HCC, and NonBNonC-HCC). In tumor-node metastasis (TNM) stages I+II, however, NonBNonC-HCC patients took the most favorable clinical course. The incidence of NonBNonC-HCC in all HCC was 5–8% from 1991 to 1998, and has increased to 10–12% since 1999. Additionally, the incidence of HBcAb-positive HCC in NonBNonC-HCC declined each year. Among NonBNonC-HCC patients, the morbidity of diabetic complications was significantly higher in HBcAb-negative patients than in HBcAb-positive patients. Conclusion: Although the incidence of NonBNonC-HCC among all HCC has an increasing trend recently, the incidence of HBcAb-positive HCC in NonBNonC-HCC has a tendency of decreasing. This fact suggest its etiology might be changing from occult HBV related HCC to unknown etiology such as nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) related HCC. The prognosis of NonBNonC-HCC was fairly good if the HCC was found in its early stage.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 11/24/2006
Issue release date: December 2006

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 2

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


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