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Vol. 67, No. 2, 2007
Issue release date: February 2007
Section title: Original Paper
Horm Res 2007;67:100–104
(DOI:10.1159/000096422)

Gluten-Free Diet Impact on Leptin Levels in Asymptomatic Coeliac Adolescents: One Year of Follow-Up

Maggio M.C.a · Corsello G.a · Iacono G.c · Teresi S.b · Guicciardino E.b · Terrana S.a · Liotta A.a
aDepartment ‘Materno-Infantile’, University of Palermo, bAnalysis Laboratory, and cUnit of Paediatric Gastroenterology, Children’s Hospital ‘G. Di Cristina’, Palermo, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/19/2004
Accepted: 8/8/2006
Published online: 10/19/2006
Issue release date: February 2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Coeliac disease, daily more frequently diagnosed in our population, involves many organs also in oligosymptomatic patients and with an adequate nutritional regime. Possible endocrine implications include failure to thrive, pubertal delay and reproduction diseases due to deregulation of GH, FSH and LH secretion. Leptin, an adipose tissue hormone, can be decreased as well and its deficiency could be related to growth and puberty anomalies. We studied 14 asymptomatic coeliac patients in peripubertal age (7.5–13.8 years) and tested their leptin levels in order to correlate them with endocrine and anthropometric data. Before the diet was started leptinaemia (M±DS) was: 4.94 ± 5.53 ng/ml. In 10/14 patients (71%) leptinaemia was ≤2 DS for gender and age. In all the patients, after a period of 6–12 months of gluten-free diet, Leptin levels appreciably raised to 10.8 ± 7.9 ng/ml, with a significant correlation to the time of the diet. Leptinaemia was actually lower in patients with a severe mucosal atrophy, and in these patients it increased more significantly after the diet was started. The removal of gluten itself may reduce immunological hit to adipose tissue and the ‘malnutrition’ of adipocytes: leptin can hence increase despite no significant increase of body mass index occurs. This study could partially explain the correlation between body mass index, Coeliac disease and the deregulation of puberty and fertility, mainly in patients who started the diet late. It could also explain the reversibility of this alteration if the cause is removed.

© 2007 S. Karger AG, Basel


  

Author Contacts

Dr. Maria Cristina Maggio
Dipartimento Universitario Materno-Infantile, Università degli Studi di Palermo
Via Cardinale Mariano Rampolla, 1
IT–90142 Palermo (Italy)
Tel. +39 09 162 55 798, Fax +39 09 165 55 429, E-Mail benfri@diseg.unipa.it

  

Article Information

Received: October 19, 2004
Accepted: August 8, 2006
Published online: October 19, 2006
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 2, Number of References : 22

  

Publication Details

Hormone Research (From Developmental Endocrinology to Clinical Research)

Vol. 67, No. 2, Year 2007 (Cover Date: February 2007)

Journal Editor: Czernichow, P. (Paris)
ISSN: 0301–0163 (print), 1423–0046 (Online)

For additional information: http://www.karger.com/HRE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/19/2004
Accepted: 8/8/2006
Published online: 10/19/2006
Issue release date: February 2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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