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Cover

Mechanisms of Dietary Restriction in Aging and Disease

Editor(s): Mobbs C.V. (New York, N.Y.) 
Yen K. (New York, N.Y.) 
Hof P.R. (New York, N.Y.) 
Table of Contents
Vol. 35, No. , 2007
Section title: Paper
Mobbs CV, Yen K, Hof PR (eds): Mechanisms of Dietary Restriction in Aging and Disease. Interdiscipl Top Gerontol. Basel, Karger, 2007, vol 35, pp 98-114
(DOI:10.1159/000096558)

Dietary Restriction in the Nematode Caenorhabditis elegans

Houthoofd K.a,b · Gems D.b · Johnson T.c · Vanfleteren J.a
aDepartment of Biology, Ghent University, Ghent, Belgium; b Department of Biology, UCL Centre for Research on Ageing, University College London, London, UK; cDepartment of Integrative Physiology, Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colo., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: October 20, 2006
Cover Date: 2007

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8170-7 (Print)
eISBN: 978-3-318-01390-0 (Online)

Abstract

The nematode Caenorhabditis elegans has proved to be an excellent model organism for the study of development and aging. Many aging mutants have been discovered in the past two decades, and much has been discovered about the physiology of long-lived mutants. It therefore seems surprising that dietary restriction (DR) has not been extensively studied using C. elegans. The main reason for this is the lack of an ideal method to subject C. elegans to DR. However, several authors have tried to study the effect of DR on the metabolism and physiology of C. elegans, and epistasis-type interaction studies have been carried out in order to detect genes that might be involved in DR effects. These studies show that DR life extension is not caused by a reduced metabolic rate, consistent with results in other species. Moreover, the well-known insulin/IGF-1 pathway seems not to mediate life-extending effects. One possibility is that target of rapamycin signaling mediates the effects of DR on life span in C. elegans.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: October 20, 2006
Cover Date: 2007

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8170-7 (Print)
eISBN: 978-3-318-01390-0 (Online)


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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