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Vol. 23, No. 1, 2007
Issue release date: December 2006
Section title: Original Research Article
Dement Geriatr Cogn Disord 2007;23:29–34
(DOI:10.1159/000096636)

Metabolic Syndrome and Cognitive Function: A Population-Based Follow-Up Study in Elderly Women

Komulainen P. · Lakka T.A. · Kivipelto M. · Hassinen M. · Helkala E.-L. · Haapala I. · Nissinen A. · Rauramaa R.
aKuopio Research Institute of Exercise Medicine and bInstitute of Biomedicine, Department of Physiology, cDepartment of Neuroscience and Neurology, dDepartment of Public Health and General Practice, University of Kuopio, and eDepartment of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, and fDepartment of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland; gAging Research Center, Karolinska Institutet, Stockholm, Sweden; hDepartment of Nutrition and Dietetics, King’s College London, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 9/6/2006
Published online: 10/27/2006

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Objective: To test the hypothesis that metabolic syndrome predicts cognitive impairment, and to examine the association of single metabolic risk factors with cognitive functioning. Methods: Weperformed a 12-year follow-up study in a population-based sample of 101 women aged 60–70 years at baseline. Metabolic syndrome wasdefined by the National Cholesterol Education Program criteria (≧3 out of 5 risk factors). Global cognitive function was measured by the Mini-Mental State Examination both at baseline and follow-up. A detailed neuropsychological evaluation for memory and cognitive speed was performed at follow-up. Results: The prevalence of metabolic syndrome increased from 13% at baseline to 49% at follow-up (p < 0.001). Women with metabolic syndrome at baseline had a 4.27 (95% confidence interval: 1.02–17.90; p = 0.047) times higher risk of poor memory at follow-up after adjustment for age, education and depression. The increasing number of metabolic risk factors was associated with worsening of memory at follow-up (p = 0.034 for linear trend). Women with low baseline levels of high-density lipoprotein (HDL) cholesterol were more likely to have poor memory at follow-up than those with higher HDL levels (p = 0.028). The risk of having poor memory increased by 46.5% (95% confidence interval: 15–66%; p = 0.008) with 1 SD decrease in HDL cholesterol level. Conclusion: In elderly women, metabolic syndrome may be an important contributor to worsening of memory, which is an essential part of mild cognitive impairment.


  

Author Contacts

Pirjo Komulainen
Kuopio Research Institute of Exercise Medicine
Haapaniementie 16
FI–70100 Kuopio (Finland)
Tel. +358 17 288 4422, Fax +358 17 288 4488, E-Mail Pirjo.Komulainen@uku.fi

  

Article Information

Accepted: September 6, 2006
Published online: October 27, 2006
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 2, Number of References : 30

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 23, No. 1, Year 2007 (Cover Date: December 2006)

Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 9/6/2006
Published online: 10/27/2006

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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