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Table of Contents
Vol. 63, No. 3, 2007
Issue release date: April 2007
Section title: Original Article
Gynecol Obstet Invest 2007;63:155–162
(DOI:10.1159/000096893)

Tensile Strength and Host Response towards Silk and Type I Polypropylene Implants Used for Augmentation of Fascial Repair in a Rat Model

Spelzini F.a, d · Konstantinovic M.L.a · Guelinckx I.a · Verbist G.d · Verbeken E.b · De Ridder D.c · Deprest J.a, d
aCentre for Surgical Technologies, Faculty of Medicine, bDepartment of Pathology, and Pelvic Floor Centre of the Departments of cUrologyand dObstetrics & Gynaecology , University Hospital ‘Gasthuisberg’, Katholieke Universiteit Leuven, Leuven, Belgium

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: May 18, 2006
Accepted: June 14, 2006
Published online: November 08, 2006
Issue release date: April 2007

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Objective: We compared host response, architectural integration and tensile strength of two different macroporous silk constructs to a polypropylene type I implant in a rat model for augmentation of primary fascial defect repair. Materials and Methods: Animals were sacrificed on days 7, 14, 30 and 90 after implantation. The explants were evaluated macroscopically for infections, herniations and adhesions, mechanically for tensile strength, and histopathologically, to evaluate collagen deposition and inflammatory response. Results: The tensile strength of the explants showed a gradual increase for all materials. All implants uniformly shrank around one fifth by 90 days. In the silk implants, the inflammatory reaction showed a remarkable higher number of foreign body giant cells that characteristically spread from the periphery into implants. Collagen deposition was comparable for all the materials. In Silk a higher grade of neovascularisation was observed. Conclusion: Silk explants expressed high tensiometric strength, which was associated with a marked fibrotic process. The silk implants induced a strong foreign body reaction accompanied by microscopic signs of architectural degradation at 90 days. Polypropylene explants showed a more moderate foreign body reaction without architectural disturbance.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: May 18, 2006
Accepted: June 14, 2006
Published online: November 08, 2006
Issue release date: April 2007

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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