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Vol. 214, No. 1, 2007
Issue release date: December 2006
Section title: Pharmacology and Treatment
Dermatology 2007;214:61–67
(DOI:10.1159/000096915)

The Steroid-Sparing Effect of an Emollient Therapy in Infants with Atopic Dermatitis: A Randomized Controlled Study

Grimalt R.a · Mengeaud V.b · Cambazard F.c
aHospital Clinic, University of Barcelona, Barcelona, Spain; bInstitut de Recherche Pierre Fabre, Ramonville, and cService de Dermatologie, Hôpital Nord, Saint-Etienne, France

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: 6/9/2006
Accepted: 7/21/2006
Published online: 12/22/2006
Issue release date: December 2006

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: No study has clearly demonstrated the steroid-sparing effect of emollients in the treatment of atopic dermatitis (AD). Aim: Evaluating the effect of an emollient containing oat extracts on the amount of topical corticosteroids used in infants with moderate to severe AD. Study Design: During 6 weeks, 173 infants under 12 months old treated for inflammatory lesions by moderate- and/or high-potency topical corticosteroids randomly received the emollient or not (control group). Methods: Evaluation of corticosteroid consumption by weighing the tubes, disease severity by the Scoring Atopic Dermatitis Index (SCORAD), and infants’ and parents’ quality of life by Infant’s Dermatitis Quality of Life Index and Dermatitis Family Impact scores at D0, D21 and D42. Results: Compared to the control group, the amount of moderate- and high-potency corticosteroids used in 6 weeks decreased by 7.5% (not significant) and 42% (p < 0.05), respectively, in the emollient group. The SCORAD index, and infants’ and parents’ quality of life significantly improved (p < 0.0001) in both groups. Conclusion: The emollient treatment significantly reduced the high-potency topical corticosteroid consumption in infants with AD.

© 2007 S. Karger AG, Basel


  

Author Contacts

Prof. Ramon Grimalt
Department of Dermatology, Hospital Clinic, University of Barcelona
Villarroel 170
ES–08036 Barcelona (Spain)
Tel. +34 93 780 11 15, Fax +34 93 780 00 11, E-Mail grimalt@ub.edu

  

Article Information

French Study Investigators: Auzerie Valérie, MD; Bodokh Isaac, MD; Boghanim Albert, MD; Bohu Pascale, MD; Bonnevalle Annie, MD; Bouillot Fabrice, MD; Cambon Laurent, MD; Cnudde François, MD; Colson Jean, MD; De Paz Gilbert, MD; De Seguin Des Hons Catherine, MD; Eschard Catherine, MD; Fouchard Nathalie, MD; Garreau Dominique, MD; Hache Didier, MD; Hugon Gérard, MD; Lavillonniere Lise, MD; Le Corre Yves, MD; Legrele Gérard, MD; Limonier Philippe, MD; Lulin Jacques, MD; Lustig Marie-Joséphine, MD; Mauboussin Martine, MD; Menu-Guillemin Stephan, MD; Meyer Jean-Yves, MD; Moraillon Isabelle, MD; Mortureux Patricia, MD; Neau Arielle, MD; Perrussel Marc, MD; Petrus Marc, MD; Peyron Jean-Louis, MD; Plantin Patrice, MD; Prud’homme Philippe, MD; Reverte Marc, MD; Rivière Claude, MD; Robert Jacques, MD; Rostain Gilles, MD; Sans Béatrix, MD; Soubrane Jean-Claude, MD; Souillet Anne-Laure, MD; Toulemonde Anne, MD.

Received: June 9, 2006
Accepted: July 21, 2006
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 1, Number of References : 33

  

Publication Details

Dermatology

Vol. 214, No. 1, Year 2007 (Cover Date: December 2006)

Journal Editor: Saurat, J.-H. (Geneva)
ISSN: 1018–8665 (print), 1421–9832 (Online)

For additional information: http://www.karger.com/DRM


Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: 6/9/2006
Accepted: 7/21/2006
Published online: 12/22/2006
Issue release date: December 2006

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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