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Table of Contents
Vol. 27, No. 4, 2006
Issue release date: December 2006
Section title: Original Paper
Neuroepidemiology 2006;27:222–229
(DOI:10.1159/000096994)

The Changing Risk Factor Profile of Participants Enrolled in a Secondary Stroke Prevention Trial: Vitamin Intervention for Stroke Prevention

Howard V.J.a · Furie K.L.b · Wang C.-H.c · Sides E.G.d, e · Toole J.F.d
aDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Ala., bMassachusetts General Hospital, Boston, Mass., cFamily Health International, Research Triangle,N.C., dStroke Center and eDepartment of Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, N.C., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 14, 2006
Published online: December 13, 2006
Issue release date: December 2006

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 3

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

Objective: To determine if the stroke risk factor profile of participants in a large, multicenter secondary stroke prevention trial changed over the recruitment period. Methods: The 3,680 participants in the Vitamin Intervention for Stroke Prevention (VISP) were categorized into four groups by enrollment date. Baseline patient characteristics and stroke risk factors were compared across groups. Results: Hypertension and hypercholesterolemia management improved but prevalence of three major stroke risk factors did not change. Patients enrolled later had better Mini-Mental State and lower NIH Stroke Scale scores, higher multivitamin use, lower prevalence of cortical infarctions, cardiac symptoms and prior stroke, and lower serum creatinine levels. Conclusions: Those participants enrolled in the later recruitment periods had a different risk factor profile and risk factors were managed differently compared to those enrolled earlier.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 14, 2006
Published online: December 13, 2006
Issue release date: December 2006

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 3

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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