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Table of Contents
Vol. 1, No. 3, 1994
Issue release date: 1994
Section title: Original Paper
Neuroimmunomodulation 1994;1:181–187
(DOI:10.1159/000097159)

Localization of Stem Cell Factor mRNA in Adult Rat Hippocampus

Wong M. · Licinio J.
Clinical Neuroendocrinology Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, Md., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 26, 1994
Accepted: March 09, 1994
Published online: May 21, 2010
Issue release date: 1994

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM

Abstract

Stem cell factor (SCF) promotes the growth of multilineage hematopoietic cells. SCF is a product of the steel (Sl) locus of the mouse, and it is a ligand for the c-kit proto-oncogene receptor. Previous studies have investigated the distribution of SCF mRNA in developing and adult tissues of the rat, including the brain. However, there have been conflicting reports on the distribution of SCF mRNA in adult rat brain. Specially noteworthy was one report of the absence of SCF mRNA in adult hippocampus, while another group reported the presence of that mRNA in the dentate gyrus of the hippocampus. We conducted this study to determine the precise localization of SCF mRNA in adult brain, and were especially interested in determining whether that mRNA is localized in adult hippocampus. We used in situ hybridization histochemistry to demonstrate that the gene encoding SCF is actively expressed in neuron-like cells in various regions of adult rat brain. Our data show that SCF mRNA is present in neuron-like cells in the thalamus, cerebral cortex, cerebellum, and hippocampus, particularly in the dentate gyrus, but also in CA1, CA2, and CA3. We did not localize SCF mRNA in glia-Iike cells. Dyskeratosis congenita is a severe human disorder, associated with dyskeratosis, anemia, and mental retardation. It has been postulated that dyskeratosis congenita is due to a deficiency in SCF function. It is unknown why patients with dyskeratosis congenita suffer from mental retardation. We suggest that it is possible that the mental retardation observed as part of the syndrome could be related to a deficiency of SCF in developing as well as in adult brain.

© 1994 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 26, 1994
Accepted: March 09, 1994
Published online: May 21, 2010
Issue release date: 1994

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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