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Table of Contents
Vol. 2, No. 4, 1995
Issue release date: 1995
Section title: Recent Progress in Neuroimmunomodulation / Review
Neuroimmunomodulation 1995;2:241–248
(DOI:10.1159/000097202)

Passage of Cytokines across the Blood-Brain Barrier

Banks W.A..a · Kastin A.J.a · Broadwell R.D.b
aVeterans Affairs Medical Center and Tulane University School of Medicine, New Orleans, La., bOffice of Research Integrity, US Public Health Service, Rockville, Md., USA

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Article / Publication Details

First-Page Preview
Abstract of Recent Progress in Neuroimmunomodulation / Review

Published online: 3/8/1996
Issue release date: 1995

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM

Abstract

One mechanism by which blood-borne cytokines might affect the function of the central nervous system (CNS) is by crossing the blood-brain barrier (BBB) for direct interaction with CNS tissue. Saturable transport systems from blood to the CNS have been described for interleukin (IL)-1α IL-1β IL-1 receptor antagonist (IL-1ra), IL-6, and tumor necrosis factor-α (TNF-α). Blood-borne cytokines have been shown to cross the BBB to enter cerebrospinal fluid and interstitial fluid spaces of the brain and spinal cord. IL-2 does not cross the BBB by a saturable transport system. The blood-to-brain uptakes of IL-1α, IL-β, and IL-1ra are interrelated for most brain sites, but the posterior division of the septum shows selective uptake of blood-borne IL-1α. The saturable transport systems for IL-6 and TNF-α are distinguishable from each other and from the IL-1 systems. The amount of blood-borne cytokines entering the brain is modest but comparable to that of other water-soluble compounds, such as morphine, known to cross the BBB in sufficient amounts to affect brain function. CNS to blood efflux of cytokines has also been shown to occur, but the mechanism of passage is unclear. Taken together, the evidence shows that passage of cytokines across the BBB occurs, providing a route by which blood-borne cytokines could potentially affect brain function.

© 1995 S. Karger AG, Basel


  

Author Contacts

William A. Banks
VAMC
1601 Perdido Street
New Orleans, LA 70146 (USA)

  

Article Information

Received: September 6, 1995
Accepted: October 9, 1995
Number of Print Pages : 8

  

Publication Details

Neuroimmunomodulation

Vol. 2, No. 4, Year 1995 (Cover Date: 1995)

Journal Editor: Chrousos, G.P. (Bethesda, Md.)
ISSN: 1021–7401 (print), 1423–0216 (Online)

For additional information: http://www.karger.com/NIM


Article / Publication Details

First-Page Preview
Abstract of Recent Progress in Neuroimmunomodulation / Review

Published online: 3/8/1996
Issue release date: 1995

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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