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Vol. 23, No. 2, 2007
Issue release date: January 2007
Section title: Original Research Article
Dement Geriatr Cogn Disord 2007;23:87–95
(DOI:10.1159/000097354)

Differential CSF Biomarker Levels in APOE-ε4-Positive and -Negative Patients with Memory Impairment

Andersson C. · Blennow K. · Johansson S.-E. · Almkvist O. · Engfeldt P. · Lindau M. · Eriksdotter-Jönhagen M.
aDepartment of Neurobiology, Caring Sciences and Society, Karolinska Institutet, bDepartment of Psychology, Karolinska University Hospital Huddinge, and cDepartment of Psychology, Stockholm University, Stockholm, dClinical Neurochemistry Laboratory, Department of Clinical Neuroscience, University of Göteborg, Göteborg, eDepartment of Clinical Medicine, Family Medicine Research Centre, Örebro University, Örebro, and fDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University Hospital, Uppsala, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 6/26/2006
Accepted: 9/15/2006
Published online: 11/22/2006

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 5

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Objectives: To investigate the relationships between episodic memory, APOE genotype, CSF markers (total tau, T-tau; phospho-tau, P-tau; β-amyloid, Aβ42) and longitudinal cognitive decline. Methods: 124 memory clinic patients were retrospectively divided into 6 groups based on (i) episodic memory function (Rey Auditory Verbal Learning Test, RAVLT): severe, moderate or no impairment (SIM, MIM or NIM), and (ii) APOE genotype (ε4+ or ε4–). CSF marker levels and cognitive decline were compared across groups. Results: Episodic memory function, according to RAVLT scores, was significantly correlated with CSF marker levels only among ε4+ subjects and not among ε4– subjects. When comparing the 6 subgroups, SIM ε4+ and MIM ε4+ groups showed significantly lower Aβ42 levels than the other groups. T-tau and P-tau levels were significantly increased in SIM ε4+ when compared to all the other groups, including the SIM ε4– group. However, both SIM ε4+ and SIM ε4– declined cognitively during the follow-up. Conclusion: It remains to be determined whether APOE genotype affects the expression of biomarkers in CSF, or whether the different biomarker patterns reflect different types of disease processes in patients with progressive cognitive dysfunction.


  

Author Contacts

Christin Andersson
Karolinska Institutet, Novum plan 5
Karolinska University Hospital Huddinge
SE–141 86 Stockholm (Sweden)
Tel. +46 8 585 854 83, Fax +46 8 585 864 65, E-Mail christin.andersson@ki.se

  

Article Information

Accepted: September 15, 2006
Published online: November 22, 2006
Number of Print Pages : 9
Number of Figures : 1, Number of Tables : 5, Number of References : 45

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 23, No. 2, Year 2007 (Cover Date: January 2007)

Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 6/26/2006
Accepted: 9/15/2006
Published online: 11/22/2006

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 5

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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