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Vol. 67, Suppl. 1, 2007
Issue release date: February 2007
Section title: Plenary Lecture 1
Horm Res 2007;67:2–9
(DOI:10.1159/000097543)

Impact of Sleep and Sleep Loss on Neuroendocrine and Metabolic Function

van Cauter E. · Holmbäck U. · Knutson K. · Leproult R. · Miller A. · Nedeltcheva A. · Pannain S. · Penev P. · Tasali E. · Spiegel K.
aDepartments of Medicine and Health Studies, University of Chicago, Chicago, Ill., USA; bLaboratory of Physiology, Université Libre de Bruxelles, Brussels, Belgium

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Article / Publication Details

First-Page Preview
Abstract of Plenary Lecture 1

Published online: 2/15/2007

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Background: Sleep exerts important modulatory effects on neuroendocrine function and glucose regulation. During the past few decades, sleep curtailment has become a very common behavior in industrialized countries. This trend toward shorter sleep times has occurred over the same time period as the dramatic increases in the prevalence of obesity and diabetes. Aims: This article will review rapidly accumulating laboratory and epidemiologic evidence indicating that chronic partial sleep loss could play a role in the current epidemics of obesity and diabetes. Conclusions: Laboratory studies in healthy young volunteers have shown that experimental sleep restriction is associated with a dysregulation of the neuroendocrine control of appetite consistent with increased hunger and with alterations in parameters of glucose tolerance suggestive of an increased risk of diabetes. Epidemiologic findings in both children and adults are consistent with the laboratory data.


  

Author Contacts

Eve Van Cauter, MD
Department of Medicine
University of Chicago, 5841 S. Maryland Ave.
Chicago, IL 60637 (USA)
Tel. +1 773 702 0169, Fax +1 773 702 7686, E-Mail evcauter@medicine.bsd.uchicago.edu

  

Article Information

Published online: February 15, 2007
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 2, Number of References : 40

  

Publication Details

Hormone Research (From Developmental Endocrinology to Clinical Research)

Vol. 67, No. Suppl. 1, Year 2007 (Cover Date: February 2007)

Journal Editor: Czernichow, P. (Paris)
ISSN: 0301–0163 (print), 1423–0046 (Online)

For additional information: http://www.karger.com/HRE


Article / Publication Details

First-Page Preview
Abstract of Plenary Lecture 1

Published online: 2/15/2007

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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