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Vol. 105, No. 2, 2007
Issue release date: January 2007
Section title: Original Paper
Nephron Clin Pract 2007;105:c54–c57
(DOI:10.1159/000097598)

Glucocorticoid-Induced Diabetes Mellitus: Prevalence and Risk Factors in Primary Renal Diseases

Uzu T.a · Harada T.b · Sakaguchi M.a · Kanasaki M.a · Isshiki K.a · Araki S.a · Sugiomoto T.a · Koya D.c · Haneda M.d · Kashiwagi A.a · Yamauchi A.b
aDepartment of Medicine, Shiga University of Medical Science, Otsu, Shiga, bDivision of Nephrology, Osaka Rosai Hospital, Sakai, Osaka, cDepartment of Medicine, Division of Endocrinology & Metabolism, Kanazawa Medical University, Kanazawa, Ishikawa, dSecond Department of Medicine, Asahikawa Medical College, Asahikawa, Hokkaido, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/9/2006
Accepted: 8/15/2006
Published online: 11/29/2006
Issue release date: January 2007

Number of Print Pages: 1
Number of Figures: 1
Number of Tables: 2

ISSN: (Print)
eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC

Abstract

Background/Aims: In patients with primary renal diseases the current knowledge of hyperglycemia associated with corticosteroid therapy is limited. We therefore examined the prevalence and risk factors of glucocorticoid-induced diabetes mellitus (DM) in primary renal diseases. Methods: Patients were recruited with primary renal diseases who were started on corticosteroids between April 2002 and June 2005. In patients with DM, an impaired fasting glucose level and/or positive urinary glucose analyses before corticosteroids therapy were excluded. Results: During corticosteroid therapy (initial dose: prednisolone 0.75 ± 0.10 mg/kg/day), DM was newly diagnosed in 17 (40.5%) of 42 patients. All of the 17 patients were diagnosed as having DM by postprandial hyperglycemia at 2 h after lunch, although they had normal fasting blood glucose levels. Age (OR 1.40, 95% CI 1.06–1.84) and body mass index (OR 1.87, 95% CI 1.03–3.38) were determined as independent risk factors for glucocorticoid-induced DM. Conclusion: Over 40% of patients with primary renal disease developed DM during treatment with corticosteroids. A high age and high body mass index are the independent risk factors for glucocorticoid-induced DM. 24-hour urinary glucose analyses and postprandial plasma glucose are useful for detecting glucocorticoid-induced DM.

© 2007 S. Karger AG, Basel


  

Author Contacts

Takashi Uzu
Department of Medicine, Shiga University of Medical Science
Seta, Otsu, Shiga 520-2192 (Japan)
Tel. +81 77 548 2222, Fax +81 77 543 3858
E-Mail takuzu@belle.shiga-med.ac.jp

  

Article Information

Received: May 9, 2006
Accepted: August 15, 2006
Published online: November 29, 2006
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 2, Number of References : 13

  

Publication Details

Nephron Clinical Practice

Vol. 105, No. 2, Year 2007 (Cover Date: January 2007)

Journal Editor: Powis, S.H. (London)
ISSN: 1660–2110 (print), 1660–2110 (Online)

For additional information: http://www.karger.com/NEC


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/9/2006
Accepted: 8/15/2006
Published online: 11/29/2006
Issue release date: January 2007

Number of Print Pages: 1
Number of Figures: 1
Number of Tables: 2

ISSN: (Print)
eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC


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