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Vol. 20, No. 2, 2007
Issue release date: March 2007
Section title: Original Paper
Skin Pharmacol Appl Skin Physiol 2007;20:77–84
(DOI:10.1159/000097654)

Influence of Different Anesthetics on Skin Oxygenation Studied by Electron Paramagnetic Resonance in vivo

Abramovic Z. · Sentjurc M. · Kristl J. · Khan N. · Hou H. · Swartz H.M.
aLaboratory for Biophysics, Jozef Stefan Institute, and bFaculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia; cDepartment of Diagnostic Radiology, Dartmouth Medical School, Hanover, N.H., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/3/2006
Accepted: 8/21/2006
Published online: 12/1/2006

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 2

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

The effects of two general anesthetics on skin oxygenation in mice are evaluated by electron paramagnetic resonance oximetry. Up to now no data on the effects of different anesthetics on skin oxygenation could be found. In this study animals were anesthetized with ketamine/xylazine or isoflurane, and partial pressure of oxygen (pO2) in the skin, heart rate and hemoglobin oxygen saturation were followed as a function of time and inhaled oxygen concentration. The skin pO2 significantly increased continuously for about 60 min in mice anesthetized with isoflurane and remained constant after that. During ketamine/xylazine anesthesia, the pO2 in the skin only slightly decreased. The skin pO2 increased with higher inspired oxygen concentrations for both anesthetics groups. When breathing 21% oxygen, mice anesthetized with isoflurane had two-fold higher pO2 in the skin compared to mice anesthetized with ketamine/xylazine. The heart rate was significantly lower in animals anesthetized with ketamine/xylazine, while hemoglobin saturation was almost the same in both groups at all inhaled oxygen concentrations. These results show that the type of anesthesia is an important parameter that needs to be considered in experiments where skin pO2 is followed.


  

Author Contacts

Zrinka Abramovic
Jozef Stefan Institute
Laboratory for Biophysics, Jamova 39
SI–1000 Ljubljana (Slovenia)
Tel. +386 1 477 31 67, Fax +386 1 477 31 91, E-Mail zrinka.abramovic@ijs.si

  

Article Information

Received: March 3, 2006
Accepted after revision: August 21, 2006
Published online: December 1, 2006
Number of Print Pages : 8
Number of Figures : 5, Number of Tables : 2, Number of References : 31

  

Publication Details

Skin Pharmacology and Physiology (Journal of Pharmacological and Biophysical Research)

Vol. 20, No. 2, Year 2007 (Cover Date: March 2007)

Journal Editor: Lademann, J. (Berlin)
ISSN: 1660–5527 (print), 1660–5535 (Online)

For additional information: http://www.karger.com/SPP


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/3/2006
Accepted: 8/21/2006
Published online: 12/1/2006

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 2

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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