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Vol. 20, No. 2, 2007
Issue release date: March 2007
Section title: Original Paper
Skin Pharmacol Appl Skin Physiol 2007;20:112–115
(DOI:10.1159/000097983)

In vitro Antibacterial Activity of Lucilia sericata Maggot Secretions

Daeschlein G. · Mumcuoglu K.Y. · Assadian O. · Hoffmeister B. · Kramer A.
aInstitute for Hygiene and Environmental Medicine, Ernst Moritz Arndt University, Greifswald, Germany; bDepartment of Parasitology, Hebrew University-Hadassah Medical School, Jerusalem, Israel;

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/17/2006
Accepted: 10/5/2006
Published online: 12/13/2006

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Maggots of the green blowfly, Lucilia sericata, are used as an alternative to surgical intervention and long-term antiseptic therapy for the treatment of chronic wounds. The secretions of maggots are known to have antibacterial properties. To quantify the bactericidal effect of secretions from larvae of L. sericata, an in vitro test model based on the modified European quantitative suspension test (EN 1040) was developed, in which a co-culture of maggots and bacteria (Micrococcus luteus,Escherichia coli, methicillin-sensitive Staphylo-coccus aureus) in tryptic soy broth was tested. The numbers of bacterial colonies with and without maggot exposure were compared after 24, 48 and 72 h of exposure. The mean log10 reduction factor (RF) for bacterial elimination per maggot was >4 at all examined times for all tested bacteria. Thus, maggot secretion fulfilled the required definitions of an antiseptic. In addition, the maggots’ ability to ingest bacteria was also evaluated. Maggots contained viable bacteria after 48 h of contact with the respective organisms. These maggots also continued excreting bacteria. Therefore, maggots should be disposed of after use as they must be regarded as medical waste.


  

Author Contacts

Univ.-Prof. Dr. Ojan Assadian
Department of Hygiene and Medical Microbiology, Medical University Vienna Waehringer Gürtel 18–20, AT–1090 Vienna (Austria)
Tel. +43 1 40400 1904, Fax +43 1 40400 1907
E-Mail ojan.assadian@meduniwien.ac.at

  

Article Information

Received: July 17, 2006
Accepted: October 5, 2006
Published online: December 13, 2006
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 0, Number of References : 24

  

Publication Details

Skin Pharmacology and Physiology (Journal of Pharmacological and Biophysical Research)

Vol. 20, No. 2, Year 2007 (Cover Date: March 2007)

Journal Editor: Lademann, J. (Berlin)
ISSN: 1660–5527 (print), 1660–5535 (Online)

For additional information: http://www.karger.com/SPP


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/17/2006
Accepted: 10/5/2006
Published online: 12/13/2006

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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