Significance of Collagenase 3 (Matrix Metalloproteinase 13) in Invasive Bladder Cancer: Correlation with Pathological ParametersRodríguez Faba O. · Fernández Gómez J.M. · Palou Redorta J. · Escaf Barmadah S. · Vizoso F. · Villavicencio Mavrich H.
aDepartment of Urology and Pathology, University of Oviedo, Oviedo, bDepartment of Urology, Fundació Puigvert, Barcelona, and cDepartment of Surgery, Hospital of Jove, Gijón, Spain
Purpose: To determine if collagenase 3 expression is associated with stage progression and prognosis of bladder cancer. Patients and Methods: Immunohistochemical staining for collagenase 3 was carried out on serial sections from specimens of 42 patients (32 males and 10 females) who underwent radical cystectomy for bladder cancer (median follow-up, 67.2 ± 5.99 months). Results: Immunohistochemical expression of collagenase 3 was detected in 13 (31%) patients. Pathological stage was pT2 in 12 (28.57%) patients, pT3a in 7 (16.6%), pT3b in 21 (50%) and pT4 in 2 (4.76%). Four tumours (9.52%) were grade II and 38 (90.47%) were grade III. Stage and tumours >3 cm in size were associated with bladder cancer progression-free survival and overall survival. We did not find any statistical differences with collagenase 3 expression related with stage and size. Conclusions: Immunohistochemical expression of matrix metalloproteinase 13 in invasive bladder cancer is not useful as marker for transformation and invasion. These findings should be evaluated in large multicentre prospective trials.
Oscar Rodríguez Faba
Department of Urology, Fundació Puigvert
ES–08025 Barcelona (Spain)
Tel. +34 934 169 700, Fax +34 934 169 730, E-Mail firstname.lastname@example.org
Received: December 19, 2005
Accepted after revision: July 24, 2006
Number of Print Pages : 5
Number of Figures : 3, Number of Tables : 2, Number of References : 16
Vol. 78, No. 2, Year 2007 (Cover Date: February 2007)
Journal Editor: Hakenberg, O.W. (Rostock)
ISSN: 0042–1138 (print), 1423–0399 (Online)
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