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Table of Contents
Vol. 78, No. 2, 2007
Issue release date: February 2007
Section title: Original Paper
Urol Int 2007;78:155–159
(DOI:10.1159/000098075)

Effect of Age on the Response to in vitro Ischemia and Reperfusion of the Rabbit Bladder

Agartan C.A.a, d · Leggett R.E.b, c · Kogan B.A.a · Levin R.M.a-c
aDepartment of Urology, Albany Medical College, bAlbany College of Pharmacy, and cStratton VA Medical Center, Albany, N.Y., USA; dAbant Izzet Baysal University Medicine School of Duzce, Duzce, Turkey

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 08, 2006
Accepted: June 28, 2006
Published online: February 15, 2007
Issue release date: February 2007

Number of Print Pages: 5
Number of Figures: 5
Number of Tables: 0

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Background/Aims: Urinary bladder dysfunction secondary to outlet obstruction is a common condition, seen in both children and adults. Using in vitro models of ischemia/reperfusion (I/R), we compared the contractile and biochemical responses of bladders isolated from young and old rabbits. Materials and Methods: Fourteen male New Zealand White rabbits were separated into two groups of 7. Group 1 (young) included rabbits 6–7 weeks old and group 2 (old) consisted of rabbits 2 years old. Isolated bladder body strips were subjected to in vitro I/R, and the effects on contractility were determined. The strips were then frozen and stored for quantitative malondialdehyde (MDA) analysis. Results: Contractile responses of young and old rabbit bladders to all forms of stimulation – field stimulation (FS), carbachol and potassium chloride (KCl) – were equal. The rate of tension to 32 Hz FS was significantly higher for group 1 in comparison with group 2. The old and young rabbits were equally sensitive to I/R in regard to FS, but the old rabbits were more sensitive to I/R in regard to carbachol and KCl stimulation. Basal MDA concentration of both young and aged bladder strips were similar. Ischemia mediated a significant increase in MDA in bladder strips from both young and old rabbits, but the MDA level was significantly greater for the young than for the old. Conclusion: Although the level of oxidative damage was greater in the young rabbit bladders, functionally, the old rabbit bladders were more sensitive to I/R damage.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 08, 2006
Accepted: June 28, 2006
Published online: February 15, 2007
Issue release date: February 2007

Number of Print Pages: 5
Number of Figures: 5
Number of Tables: 0

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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