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Table of Contents
Vol. 14, No. 1, 2007
Issue release date: February 2007
Section title: Originalarbeit · Original Article
Forsch Komplementärmed 2007;17:9-17
(DOI:10.1159/000098135)

Mistletoe Extract Reduces the Surgical Suppression of Natural Killer Cell Activity in Cancer Patients. A Randomized Phase III Trial

Schink M.a · Tröger W.b · Dabidian A.c · Goyert A.d · Scheuerecker H.c · Meyer J.e · Fischer I.U.f · Glaser F.c
aForschungsabteilung, Verein Filderklinik e.V., Filderstadt, bKlinische Forschung Dr. Tröger, Freiburg i.Br., cChirurgische Abteilung, Filderklinik, Filderstadt, dAbteilung für Innere Medizin, Filderklinik, Filderstadt, eAbteilung für Anästhesie und Intensivmedizin, Filderklinik, Filderstadt, fBüro für Biostatistik, Tübingen, Germany

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Article / Publication Details

First-Page Preview
Abstract of Originalarbeit · Original Article

Published online: March 06, 2007
Issue release date: February 2007

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-4119 (Print)
eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK

Abstract

Background: Major surgery suppresses natural killer (NK) cell cytotoxic activity which is potentially harmful for cancer patients by favouring haematogenic tumour cell dissemination. The influence of a perioperative infusion of a standardized mistletoe extract (Iscador ®) on immune functions was tested in a prospective, sequential, randomized clinical trial. Patients and Methods: Colorectal cancer patients undergoing open tumour resection were randomly assigned to either mistletoe infusion or no additional therapy. We hypothesized that mistletoe infusion improves NK cell activity and increases expression of MHC class II antigen HLA-DR on monocytes 24 h and 7 days after surgery, respectively. For statistical analysis we used a sequential study design. The decision boundaries for the two triangular tests were calculated for altogether 62 patients. Results: The sequential study design allowed stopping the recruitment prematurely. NK cell activity differed significantly between the therapy groups 24 h after surgery (p = 0.027). The absolute number of HLA-DR molecules on monocytes did not differ 7 days after surgery. NK cell activity of patients treated with mistletoe extract did not change significantly during the course of the study (-7.9% 24 h after surgery), whereas HLA-DR expression changed significantly (-38.5% at day 7 after surgery). For control patients both parameters decreased significantly after surgery (NK cell activity: -44.4% at 24 h; HLA-DR expression: -32.9% at day 7 after surgery). Conclusion: Perioperative infusion of mistletoe extracts can prevent a suppression of NK cell activity in cancer patients. The impact of this therapy on relapse and survival should be tested in further studies.


Article / Publication Details

First-Page Preview
Abstract of Originalarbeit · Original Article

Published online: March 06, 2007
Issue release date: February 2007

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-4119 (Print)
eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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