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Vol. 30, No. 1, 2007
Issue release date: February 2007
Section title: Original Paper
Kidney Blood Press Res 2007;30:1–7
(DOI:10.1159/000098140)

Does Renal Function Influence Plasma Levels of Advanced Glycation and Oxidation Protein Products in Patients with Chronic Rheumatic Diseases Complicated by Secondary Amyloidosis?

Ryšavá R.a · Kalousová M.b · Zima T.b · Dostál C.c · Merta M.a · Tesař V.a
aDepartment of Nephrology, bInstitute of Clinical Chemistry and Laboratory Diagnostics, and cInstitute of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 12/21/2006
Issue release date: February 2007

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 4

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR

Abstract

Background: The aim of the study was to assess the contribution of carbonyl and oxidative stresses to the development of amyloidosis in patients suffering from chronic rheumatic diseases, and the potential influence of renal function to their concentrations was considered. Methods: We investigated 17 patients with chronic rheumatological diseases and histologically proven diagnosis of AA amyloidosis (group AA-RA), 26 patients suffering from rheumatoid arthritis without any signs of AA amyloidosis (group nonAA-RA) and 20 healthy volunteers (Co). In all patients, advanced glycation end products (AGEs), advanced oxidation protein products (AOPP), pregnancy-associated plasma protein A (PAPP-A) and other selected proinflammatory markers were measured. Results: An increase in serum levels of AOPP and AGEs was found in the AA-RA group in comparison with nonAA-RA patients and also with Co (p < 0.001 for all comparisons). AGEs positively correlated with serum creatinine (r = 0.67, p = 0.004) and negatively with glomerular filtration rate (r = –0.54, p = 0.027). We did not find a correlation between AOPP and any other assessed parameters including proteins and renal parameters. PAPP-A levels were not significantly increased in any group of patients (AA-RA, nonAA-RA) in comparison with Co. Conclusions: Increased plasma levels of AGEs and AOPP in the group of patients with AA-RA may have been partly explained by the diminished renal clearance. However, the increase in AOPP levels was higher than what is expected in this degree of renal failure (glomerular filtration rate in the AA-RA group corresponding to chronic kidney disease stage III).

© 2007 S. Karger AG, Basel


  

Author Contacts

Romana Ryšavá, MD, PhD
Nephrology clinic, 1st Faculty of Medicine, Charles University
U nemocnice 2
CZ–128 08 Prague 2 (Czech Republic)
Tel. +420 2 2496 2587, Fax +420 2 2496 2585, E-Mail rysavar@vfn.cz

  

Article Information

Received: January 27, 2006
Accepted: November 10, 2006
Published online: December 21, 2006
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 4, Number of References : 22

  

Publication Details

Kidney and Blood Pressure Research

Vol. 30, No. 1, Year 2007 (Cover Date: February 2007)

Journal Editor: Wanner, C. (Würzburg)
ISSN: 1420–4096 (print), 1423–0143 (Online)

For additional information: http://www.karger.com/KBR


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 12/21/2006
Issue release date: February 2007

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 4

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR


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