Distribution of Anemia Associated with Micronutrient Deficiencies Other than Iron in a Probabilistic Sample of Mexican ChildrenVillalpando S. · Pérez-Expósito A.B. · Shamah-Levy T. · Rivera J.A.
Center for Research on Nutrition and Health, Instituto Nacional de Salud Pública, Cuernavaca, Mexico
Background: This investigation aims to explore the association among anemia and vitamins A, C, and folate deficiencies in a probabilistic sample of Mexican children. Methods: Data on hemoglobin, serum vitamins A and C and folate concentrations and percent transferrin saturation (PTS) in children 0.5–11 years (n = 1,770) were extracted from the database of the probabilistic Mexican National Nutrition Survey 1999 (NNS-99). Results: Overall, 16.6% of children were anemic. Iron deficiency children with or without anemia had more frequent low serum retinol (40.6 vs. 16% and 27.7 vs. 11.9%, p < 0.05, respectively) and lower hemoglobin folate (11.5 vs. 22%, p < 0.05) than their non-iron deficiency counterparts. Mean concentrations of serum iron (p < 0.01), folate (p < 0.001) and retinol (p < 0.0001), but not ascorbic acid (p < 0.6), were significantly lower in anemic than in nonanemic children. In a linear regression model, 15% of hemoglobin variation in children was explained by retinol, folate and PTS, but not vitamin C (p <0.0001). Conclusion: Anemia was mostly associated with iron deficiency and with a lesser proportion of folate and vitamin A deficiencies. Vitamin A deficiency might be overestimated since iron deficiency may lower serum retinol concentrations. Interventions aimed to reduce anemia in this population must consider interactions between those micronutrients in designing strategies.
© 2006 S. Karger AG, Basel
Received: July 6, 2005
Accepted: July 27, 2006
Published online: December 21, 2006
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 4, Number of References : 42
Annals of Nutrition and Metabolism (European Journal of Nutrition, Metabolic Diseases and Dietetics)
Vol. 50, No. 6, Year 2006 (Cover Date: February 2007)
Journal Editor: Elmadfa, I. (Vienna)
ISSN: 0250–6807 (print), 1421–9697 (Online)
For additional information: http://www.karger.com/ANM