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Vol. 74, No. 2, 2006
Issue release date: February 2007
Section title: Original Paper
Digestion 2006;74:118–125
(DOI:10.1159/000098177)

Health-Related Quality of Life in Patients with Pancreatic Cancer

Müller-Nordhorn J.a · Roll S.a · Böhmig M.b · Nocon M.a · Reich A.a · Braun C.a · Noesselt L.a · Wiedenmann B.b · Willich S.N.a · Brüggenjürgen B.a
aInstitute of Social Medicine, Epidemiology and Health Economics and bDepartment of Medicine, Division of Hepatology and Gastroenterology, Charité University Medical Center, Berlin, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/5/2006
Accepted: 10/3/2006
Published online: 2/2/2007
Issue release date: February 2007

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 4

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

Background: Pancreatic cancer is an aggressive cancer with low survival time, with health-related quality of life (HRQoL) being of major importance. The aim of our study was to assess both generic and disease-specific HRQoL in patients with pancreatic cancer. Methods: Patients with pancreatic cancer were consecutively included at admission to hospital. HRQoL was determined with the disease-specific European Organization for Research and Treatment of Cancer (EORTC) and generic EuroQoL (EQ-5D) health status instruments. Scores of patients were compared to those of norm populations. The association of symptoms with overall HRQoL was analysed using linear regression. Results: A total of 45 patients with pancreatic cancer were included. The mean age was 64 years, 53% were females. Of all patients, 44% had metastases at the time of admission. HRQoL was significantly impaired for most EORTC and EQ-5D scales in comparison to norm populations. Symptoms of fatigue (–0.34 regression coefficient; 95% CI –0.63, –0.11) and pain (–0.21; 95% CI –0.39, –0.02) were significantly associated with impaired overall HRQoL. Conclusions: HRQoL was severely impaired in patients with pancreatic cancer. Symptom control and palliative care appear to be of particular importance.

© 2006 S. Karger AG, Basel


  

Author Contacts

Dr. Jacqueline Müller-Nordhorn, DPH
Institute of Social Medicine, Epidemiology and Health Economics
Charité University Medical Center, DE–10098 Berlin (Germany)
Tel. +49 30 450 529 026, Fax +49 30 450 529 902
E-Mail jacqueline.mueller-nordhorn@charite.de

  

Article Information

Received: May 5, 2006
Accepted: September 29, 2006
Published online: December 21, 2006
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 4, Number of References : 42

  

Publication Details

Digestion (International Journal of Gastroenterology)

Vol. 74, No. 2, Year 2006 (Cover Date: February 2007)

Journal Editor: Beglinger, C. (Basel)
ISSN: 0012–2823 (print), 1421–9867 (Online)

For additional information: http://www.karger.com/DIG


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/5/2006
Accepted: 10/3/2006
Published online: 2/2/2007
Issue release date: February 2007

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 4

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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