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Increased Levels of Nitric Oxide, Cortisol and Adrenomedullin in Patients with Chronic SchizophreniaYılmaz N.a · Herken H.b · Cicek H.K.a · Celik A.a · Yürekli M.c · Akyol Ö.d
Departments of aBiochemistry and Clinical Biochemistry and bPsychiatric Disorders, Faculty of Medicine, University of Gaziantep, Gaziantep, cDepartment of Molecular Biology, Faculty of Science and Art, University of Inonu, Malatya, and dDepartment of Biochemistry and Clinical Biochemistry, Faculty of Medicine, University of Hacettepe, Ankara, Turkey Corresponding Author
Prof. Dr. Necat Yılmaz
Department of Biochemistry and Clinical Chemistry, Faculty of Medicine
University of Gaziantep
TR–27310 Gaziantep (Turkey)
Tel. +90 342 360 1200, Fax +90 342 360 1617, E-Mail firstname.lastname@example.org
Objective: To investigate the levels of serum cortisol, dehydroepiandrosterone sulfate (DHEA-S), nitric oxide (NO) and adrenomedullin (AM) in schizophrenic patients. Subjects and Methods: Sixty-six male patients with chronic schizophrenia and 28 normal male subjects participated in this study. The duration of disease was 145 ± 120 (mean ± SD) months. Serum levels of cortisol and DHEA-S were measured by electrochemiluminescence; plasma nitrite levels as an index of NO were measured with the Griess reaction, while plasma AM concentration was measured by using high-performance liquid chromatography. Results: Patients (12.48 ± 3.2 µg/dl), as compared to controls (10.31 ± 3.1 µg/dl), had higher levels of baseline cortisol (p < 0.05). DHEA-S levels were lower in patients though this did not reach statistical significance (302 ± 156 µg/dl compared to control, 322 ± 96 µg/dl, p > 0.05). The mean levels of plasma AM and NO in the schizophrenic group (44.33 ± 5.07 pmol/l and 36.27 ± 17.6 µmol/l) were significantly higher than the levels in the control group (14.56 ± 4.03 pmol/l and 32.54 ± 7.14 µmol/l; p < 0.001, p < 0.03, respectively). There was a positive association between duration of disease and cortisol/DHEA-S ratio and cortisol level. Conclusion: The data show that schizophrenia is associated with abnormal levels of cortisol, DHEA-S, NO and AM.
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