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Table of Contents
Vol. 23, No. 3, 2007
Issue release date: February 2007
Section title: Original Research Article
Dement Geriatr Cogn Disord 2007;23:168–174
(DOI:10.1159/000098516)

Predictive Value of 6-Month Decline in ADAS-cog for Survival without Severe Alzheimer’s Disease

Helmer C.a · Andrieu S.c, d · Pérès K.a · Orgogozo J.-M.a, b · Vellas B.c, d · Dartigues J.-F.a
aINSERM U593, Université de Bordeaux-2, et bFédération de Neurologie, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, et cINSERM U558 et dCentre Hospitalier Universitaire, Toulouse, France

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: July 15, 2006
Accepted: December 11, 2006
Published online: January 11, 2007
Issue release date: February 2007

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background/Aims: To determine the predictive value of the 6-month evolution of the ADAS-cog score in initially mild to moderate Alzheimer’s disease (AD) patients on the risk of death or severe dementia (MMSE <10) within 2 years. Methods: Cognition was assessed every 6 months using the ADAS-cog scale in the Real.fr study, a cohort of AD patients. Six classes of ADAS-cog evolution were distinguished, from the severest deterioration (decline ≧7 points) to the greatest cognitive improvement (gain ≧4 points). Results: Among 536 AD patients, 53 (9.9%) had a 6-month decline of 7 points or more. This group with the severest deterioration was significantly associated with the risk of severe dementia or death at 2 years (relative risk, RR = 3.8, 95% confidence interval, CI = 2.1–6.8), even after adjustment for baseline MMSE, disability and ADAS-cog score (RR = 2.6, 95% CI = 1.4–5.0). In addition, subjects with a decline by at least 4 points were also at greater risk of severe dementia. Conclusion: These results confirm the value of the ADAS-cog scale as a judgement criterion in clinical trials since it is a good surrogate marker of long-term prognosis. The proportion of fast decliners on the ADAS-cog could be a helpful judgement criterion for future trials in AD.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: July 15, 2006
Accepted: December 11, 2006
Published online: January 11, 2007
Issue release date: February 2007

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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