Obesity and Low-Grade Inflammation among Young Finnish Men with Early-Onset AlopeciaHirsso P. · Rajala U. · Hiltunen L. · Jokelainen J. · Keinänen-Kiukaanniemi S. · Näyhä S.
aUniversity of Oulu, Department of Public Health Science and General Practice, bUnit of General Practice, Oulu University Hospital, and cOulu Health Center, Oulu, Finland
Background: Previous investigations have revealed an association of androgenetic alopecia (AGA), especially in younger subjects with severe early-onset AGA, with ischemic heart disease. Objective: To examine the possible association between early-onset alopecia and low-grade inflammation measured by high-sensitivity C-reactive protein (hs-CRP) that has been recommended for the assessment of the cardiovascular disease (CVD) risk. Methods: The study population consisted of young men (n = 727, aged 25–34 years) participating in a national survey. The grade of alopecia was assessed by a trained nurse using the Norwood/Hamilton Classification Scale. Results: Men with moderate to extensive alopecia (17%) had a higher body mass index and larger waist, upper arm, hip and waist circumference than those with little to no alopecia (p < 0.05), and statistically insignificant differences were seen in the waist-to-hip circumference ratio (WHR), diastolic blood pressure and hs-CRP. With increasing hs-CRP, the mean WHR increased, but only among men with moderate to extensive alopecia (p = 0.043). Conclusion: Our findings show a relation between moderate to extensive alopecia and low-grade inflammation – a predictor of a future CVD – especially combined with central obesity, among men younger than 35 years.
Department of Public Health Science and General Practice
University of Oulu, PO Box 5000
FI–900014 Oulu (Finland)
Tel. +358 8 537 5673, Fax +358 8 537 5661, E-Mail firstname.lastname@example.org
Received: July 20, 2006
Accepted: August 13, 2006
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 1, Number of References : 26
Vol. 214, No. 2, Year 2007 (Cover Date: March 2007)
Journal Editor: Saurat, J.-H. (Geneva)
ISSN: 1018–8665 (print), 1421–9832 (Online)
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