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Vol. 214, No. 2, 2007
Issue release date: March 2007
Section title: Clinical and Laboratory Investigation
Dermatology 2007;214:125–129
(DOI:10.1159/000098570)

Obesity and Low-Grade Inflammation among Young Finnish Men with Early-Onset Alopecia

Hirsso P. · Rajala U. · Hiltunen L. · Jokelainen J. · Keinänen-Kiukaanniemi S. · Näyhä S.
aUniversity of Oulu, Department of Public Health Science and General Practice, bUnit of General Practice, Oulu University Hospital, and cOulu Health Center, Oulu, Finland

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: 7/20/2006
Accepted: 8/13/2006
Published online: 3/9/2007

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Previous investigations have revealed an association of androgenetic alopecia (AGA), especially in younger subjects with severe early-onset AGA, with ischemic heart disease. Objective: To examine the possible association between early-onset alopecia and low-grade inflammation measured by high-sensitivity C-reactive protein (hs-CRP) that has been recommended for the assessment of the cardiovascular disease (CVD) risk. Methods: The study population consisted of young men (n = 727, aged 25–34 years) participating in a national survey. The grade of alopecia was assessed by a trained nurse using the Norwood/Hamilton Classification Scale. Results: Men with moderate to extensive alopecia (17%) had a higher body mass index and larger waist, upper arm, hip and waist circumference than those with little to no alopecia (p < 0.05), and statistically insignificant differences were seen in the waist-to-hip circumference ratio (WHR), diastolic blood pressure and hs-CRP. With increasing hs-CRP, the mean WHR increased, but only among men with moderate to extensive alopecia (p = 0.043). Conclusion: Our findings show a relation between moderate to extensive alopecia and low-grade inflammation – a predictor of a future CVD – especially combined with central obesity, among men younger than 35 years.


  

Author Contacts

Päivi Hirsso
Department of Public Health Science and General Practice
University of Oulu, PO Box 5000
FI–900014 Oulu (Finland)
Tel. +358 8 537 5673, Fax +358 8 537 5661, E-Mail paivi.hirsso@oulu.fi

  

Article Information

Received: July 20, 2006
Accepted: August 13, 2006
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 1, Number of References : 26

  

Publication Details

Dermatology

Vol. 214, No. 2, Year 2007 (Cover Date: March 2007)

Journal Editor: Saurat, J.-H. (Geneva)
ISSN: 1018–8665 (print), 1421–9832 (Online)

For additional information: http://www.karger.com/DRM


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: 7/20/2006
Accepted: 8/13/2006
Published online: 3/9/2007

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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