Cover

Otosclerosis and Stapes Surgery

Editor(s): Arnold W. (Munich) 
Häusler R. (Bern) 
Table of Contents
Vol. 65, No. , 2007
Section title: Paper
Arnold W, Häusler R (eds): Otosclerosis and Stapes Surgery. Adv Otorhinolaryngol. Basel, Karger, 2007, vol 65, pp 300-307
(DOI:10.1159/000098849)

Protecting the Cochlea during Stapes Surgery: Is There a Role for Corticosteroids?

Kiefer J. · Ye Q. · Tillein J. · Adunka O. · Arnold W. · Gstöttner W.
aKlinik für Hals-Nasen-Ohrenheilkunde, Klinikum rechts der Isar, Technische Universität München, Munich, b Klinik für Hals-Nasen-Ohrenheilkunde und cZentrum der Physiologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 1/16/2007
Cover Date: 2007

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8113-4 (Print)
eISBN: 978-3-318-01343-6 (Online)

Abstract

The aim of the present study was to evaluate possible protective effects of corticosteroids on the inner ear after surgical trauma and to exclude any ototoxicity. A corticosteroid (triamcinolone, Volon A®) was topically applied to the inner ear of guinea pigs, either by extracochlear application with permeation and diffusion through the round window membrane or by intracochlear application with direct infusion into the inner ear via a cochleostomy. Threshold and input/output functions of compound action potentials (CAPs) were determined before and after application of the corticosteroid. We found that extracochlear application of the corticosteroid induced insignificant mild shifts of mean CAP thresholds, but significantly increased mean maximal amplitudes of input/output function after the 14th day following application of the steroid. No detrimental effects on cochlear function were noted in the extracochlear group, indicating absence of ototoxicity with the concentrations used. In the intracochlear group, CAP thresholds and amplitudes of input/ output function recovered from partial hearing loss due to cochleostomy between 7 and 14 days after application of the steroid, whereas in controls without steroid application, no such recovery of hearing was detected. These results suggest that topical application of triamcinolone has no ototoxic effect and that it leads to increased recovery of cochlear functions after trauma in the guinea pig inner ear.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 1/16/2007
Cover Date: 2007

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8113-4 (Print)
eISBN: 978-3-318-01343-6 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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