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Vol. 27, No. 1, 2007
Issue release date: March 2007
Section title: Original Report: Patient-Oriented, Translational Research
Am J Nephrol 2007;27:70–74
(DOI:10.1159/000099035)

Effects of α-Lipoic Acid on the Plasma Levels of Asymmetric Dimethylarginine in Diabetic End-Stage Renal Disease Patients on Hemodialysis: A Pilot Study

Chang J.W. · Lee E.K. · Kim T.H. · Min W.K. · Chun S. · Lee K.-U. · Kim S.B. · Park J.S.
Departments of aInternal Medicine and bDiagnostic Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: 2/28/2006
Accepted: 12/21/2006
Published online: 1/26/2007

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

Background/Aim: Endothelial dysfunction due to reduced nitric oxide (NO) availability precedes the development of atherosclerosis. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase, is not only a cause of endothelial dysfunction, but also a predictor of the cardiovascular outcome in end-stage renal disease (ESRD) patients on hemodialysis (HD). α-Lipoic acid (ALA), a strong antioxidant, increases NO-mediated vasodilation in diabetic patients. We investigated whether ALA could decrease the plasma level of ADMA in diabetic ESRD patients on HD. Methods: Fifty patients undergoing HD three times per week were randomized to a treatment group receiving ALA 600 mg/day for 12 weeks or a control group. We measured the plasma levels of cholesterol, albumin, high-sensitivity C-reactive protein, oxidized low-density lipoprotein, hemoglobin A1c, and ADMA in both groups at baseline and at 12 weeks. Results: In the control group, the levels of total cholesterol, serum albumin, high-sensitivity C-reactive protein, oxidized low-density lipoprotein, hemoglobin A1c, and ADMA did not change. In the treatment group, the plasma levels of ADMA decreased significantly from a median of 1.68 (range 0.45–3.78) µM to a median of 1.31 (range 0.25–3.19) µM (p = 0.001). Conclusion: Considering that ADMA is an independent risk factor for cardiovascular outcome in ESRD patients, ALA may have the potential of a beneficial effect in them, in part by decreasing the plasma level of ADMA.


  

Author Contacts

Jung Sik Park, MD
Department of Internal Medicine, University of Ulsan College of Medicine
Song-pa, PO Box 145
Seoul 138-736 (Korea)
Tel. +82 2 3010 3262, Fax +82 2 3010 6963, E-Mail jspark@amc.seoul.kr

  

Article Information

Received: August 28, 2006
Accepted: December 21, 2006
Published online: January 26, 2007
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 2, Number of References : 18

  

Publication Details

American Journal of Nephrology

Vol. 27, No. 1, Year 2007 (Cover Date: March 2007)

Journal Editor: Bakris, G. (Chicago, Ill.)
ISSN: 0250–8095 (print), 1421–9670 (Online)

For additional information: http://www.karger.com/AJN


Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: 2/28/2006
Accepted: 12/21/2006
Published online: 1/26/2007

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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