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Table of Contents
Vol. 64, No. 2, 2007
Issue release date: August 2007
Section title: Original Article
Gynecol Obstet Invest 2007;64:65–68
(DOI:10.1159/000099149)

Midtrimester Amniotic Fluid Leptin and Insulin Levels and Subsequent Gestational Diabetes

D’Anna R.a · Baviera G.a · Cannata M.L.a · De Vivo A.a · Di Benedetto A.b · Corrado F.a
Departments of aObstetrics and Gynecology and bInternal Medicine, University of Messina, Messina, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: August 09, 2006
Accepted: December 18, 2006
Published online: January 30, 2007
Issue release date: August 2007

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Aims: To evaluate midtrimester amniotic fluid leptin levels in pregnancies subsequently complicated by gestational diabetes. Methods: We studied 32 pregnant women with gestational diabetes and a control group of 43 normal pregnancies with an adequate gestational age fetus. All underwent a midtrimester amniocentesis: leptin and insulin were measured in the amniotic fluid. Data were compared with the Mann-Whitney U-test. Results: Median leptin concentrations in the amniotic fluid of the gestational diabetes mellitus patients were significantly higher than in the control group (15.1 vs. 7.9 ng/ml) (p = 0.001); amniotic insulin concentrations were also higher in the gestational diabetes mellitus than in the control group (0.67 vs. 0.38 µU/ml) (p = 0.02). Furthermore, amniotic fluid leptin levels were directly correlated with amniotic insulin concentrations; instead, there was no correlation with maternal BMI and birth weight. Conclusion: Our data suggest that in pregnancies subsequently complicated by gestational diabetes, amniotic fluid leptin and insulin levels are higher in the early fetal period.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: August 09, 2006
Accepted: December 18, 2006
Published online: January 30, 2007
Issue release date: August 2007

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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